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Investigation of the serum vitamin D level in infants followed up with the diagnosis of laryngomalacia: a case–control study

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

The possible etiological relationship of the vitamin D with laryngomalacia is unclear. The aim of the study was to demonstrate the relationship between laryngomalacia and vitamin D levels.

Methods

Twenty-three non-syndromic babies under the age of 1 year who were diagnosed with laryngomalacia were included in the study group. Forty healthy babies were included in the control group. The detailed anamnesis was obtained and a complete systemic physical examination, a flexible endoscopic laryngeal examination, and laboratory tests [calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH), alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), creatinine (Cre), and 25-hydroxy vitamin D (25-OH D)] were performed in all patients. All laboratory tests of the groups were compared.

Results

It was observed that there was no significant difference in the parameters that could affect vitamin D levels, namely type of feeding, vitamin D supplement intake, and the season when the serum sample was taken (p > 0.05). The vitamin D level was significantly lower (p = 0.003, p < 0.05) and the P and ALP levels were significantly higher (p = 0.016 and p = 0.001, respectively; p < 0.05) in the laryngomalacia group. Although the correlation between vitamin D and PTH was not statistically significant according to the Pearson correlation analysis, it was lower in the laryngomalacia group compared to the control group (p = 0.381, p > 0.05).

Conclusion

In this study, it was observed that the vitamin D levels were lower in infants with laryngomalacia compared to the control group. We consider that vitamin D deficiency may be a factor in the etiology of laryngomalacia with a yet-to-be-clarified etiology.

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Authors and Affiliations

  1. Department of Pediatrics, Kafkas Unıversity, Kars, Turkey

    Hayrunnisa Bekis Bozkurt

  2. Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Beykent Unıversity, Istanbul, Turkey

    Mustafa Çelik

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  1. Hayrunnisa Bekis Bozkurt
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  2. Mustafa Çelik
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Correspondence to Mustafa Çelik.

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Bozkurt, H.B., Çelik, M. Investigation of the serum vitamin D level in infants followed up with the diagnosis of laryngomalacia: a case–control study. Eur Arch Otorhinolaryngol 278, 733–739 (2021). https://doi.org/10.1007/s00405-020-06412-x

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  • DOI: https://doi.org/10.1007/s00405-020-06412-x

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