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Oncological outcomes of preoperatively unexpected malignant tumors of the parotid gland

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Unexpected parotid cancers are often encountered due to inaccuracies in the preoperative evaluation. This study aimed to examine the clinical characteristics and oncological outcomes of these cancers and to propose the appropriate management strategy.

Methods

This is a multicenter case series study in which a total of 302 patients were diagnosed postoperatively with parotid cancers between 2003 and 2017. Of these, 85 cases without evidence of malignancy prior to surgery but identified as malignant on postoperative pathology were included.

Results

Of 85 patients, 76 and 9 underwent superficial and total parotidectomy, respectively. A positive resection margin was present in 24.7% of the cases. Postoperative radiotherapy was administered to 43.6% of patients; 4.2% had a local recurrence, and no patients died of the disease. The 5-year overall and relapse-free survival rates were 100.0% and 95.2%, respectively. Patients who underwent piecemeal resection had significantly poorer oncologic outcomes. Age, sex, histologic grade, T stage, extracapsular extension, resection margin status, and postoperative radiotherapy did not affect recurrence and survival.

Conclusion

Preoperatively unexpected parotid cancers had excellent local control and overall survival despite positive or close resection margin, with or without postoperative radiotherapy. Therefore, patients with unexpected parotid malignancies may benefit from less aggressive postoperative management option.

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Data availability

Not applicable. The data in this study is not deposited.

Code availability

Not applicable.

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Acknowledgements

We would like to thank Editage (www.editage.co.kr) for English language editing

Funding

This study was not funded.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea

    Hanaro Park

  2. Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Sungjun Han

  3. Department of Otorhinolaryngology-Head and Neck Surgery, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Sung Joon Park

  4. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea

    Young Ho Jung, Soon-Hyun Ahn & Woo-Jin Jeong

  5. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University, College of Medicine, Seoul, South Korea

    Soon-Hyun Ahn

Authors
  1. Hanaro Park
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Contributions

Conceptualization: W-JJ, HP, S-HA; Methodology: W-JJ, HP, YHJ; Formal analysis and investigation: HP, SH, SJP; Writing—original draft preparation: W-JJ, HP; Writing—review and editing: W-JJ, HP, SH, SJP, YHJ; Supervision: W-JJ, S-HA.

Corresponding author

Correspondence to Woo-Jin Jeong.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Human Investigation Committee (Institutional Review Board) of Seoul National University Bundang Hospital approved this study.

Consent to participate

This study was granted waiver of informed consent to participate from the Human Investigation Committee (Institutional Review Board) of Seoul National University Bungdang Hospital. This permission is based on the following reasons:

1. Obtaining informed consent is not practical in the course of research or has a significant impact on the validity of the research.

2. There is no reason to presume the subject’s refusal to consent, and even if the consent is waived, the risk to the subject is extremely low.

Consent for publication

This study was granted waiver of informed consent from the Human Investigation Committee (Institutional Review Board) of Seoul National University Bundang Hospital. This permission is based on the following reasons:

1. Obtaining informed consent is not practical in the course of research or has a significant impact on the validity of the research.

2. There is no reason to presume the subject’s refusal to consent, and even if the consent is waived, the risk to the subject is extremely low.

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Park, H., Han, S., Park, S.J. et al. Oncological outcomes of preoperatively unexpected malignant tumors of the parotid gland. Eur Arch Otorhinolaryngol 278, 2033–2040 (2021). https://doi.org/10.1007/s00405-020-06317-9

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  • DOI: https://doi.org/10.1007/s00405-020-06317-9

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