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Is otitis media with effusion associated with Samter’s triad a new nosological entity? A preliminary report on inflammatory mediator production

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Otitis media with effusion (OME) associated with Samter’s triad (ST) is a difficult entity to treat. The aim of study was an investigation of the middle ear and nasal production of inflammatory mediators (IM) in patients with ST and analysing differences between them and controls.

Methods

Prospective case–control study. Nineteen patients with OME (five had allergic rhinitis, four had nasopharyngeal lymphoid hyperplasia, five had no evident sino-nasopharyngeal disease and five had confirmed ST) and 15 healthy participants were included. The concentrations of IM interleukin–1 beta (IL-1β), interferon-alpha 2 (IFN-α2), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23 and IL-33 were measured in nasal and middle ear secretions.

Results

There was a difference that was close to a level of statistical significance only for IL-1β levels in middle ear fluid (p = 0.052) between the ST subgroup and the other patients with OME. Also, we found a significant difference for IL-23 in nasal secretions between these subgroups (p = 0.040), whereas the difference in nasal fluid IL-33 was close to a level of statistical significance (p = 0.052). There was a significant difference in nasal concentrations of IL-1β, IFN-α2, MCP-1, IL-8, IL-18 and IL-33 (p < 0.001, p = 0.005, p = 0.008, p = 0.011, p = 0.011 and p = 0.011, respectively) between the OME group and the healthy subjects. There were significant positive correlations between concentrations of IL-1β, IFN-α2, IFN-γ, TNF-α, MCP-1, IL-17A, IL-18 and IL-33 (p < 0.001, p < 0.001, p = 0.002, p = 0.028, p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively) in nasal and middle ear secretions.

Conclusion

This preliminary report showed some differences in IM production between the patients with OME associated with ST and those without it. Our results suggest a uniformity of the production of nasal and middle ear IM and supported the concept of a united airway respiratory disease.

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Authors and Affiliations

  1. Faculty of Medicine, School of Medicine, Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre Serbia, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia

    Ljiljana Čvorović, Aleksandar Trivić, Zoran Dudvarski, Ana Jotić, Miljan Folić & Nenad Arsović

  2. Faculty of Medicine, Institute for Medical Statistics, University of Belgrade, Belgrade, Serbia

    Zoran Bukumirić

  3. Department of Otorhinolaryngology, Military Medical Academy Faculty of Medicine, Belgrade, Serbia

    Uglješa Grgurević & Aleksandar Perić

  4. Division of Clinical and Experimental Immunology, Military Medical Academy Faculty of Medicine, Institute for Medical Research, Belgrade, Serbia

    Danilo Vojvodić

Authors
  1. Ljiljana Čvorović
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Correspondence to Ljiljana Čvorović.

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Čvorović, L., Trivić, A., Dudvarski, Z. et al. Is otitis media with effusion associated with Samter’s triad a new nosological entity? A preliminary report on inflammatory mediator production. Eur Arch Otorhinolaryngol 278, 1835–1843 (2021). https://doi.org/10.1007/s00405-020-06276-1

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  • DOI: https://doi.org/10.1007/s00405-020-06276-1

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