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Prognostic nomogram based on immune scores for laryngeal squamous cell cancer

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Immune scores have been used as a prognostic factor for various types of cancer. However, the association between immune scores and the prognosis of laryngeal squamous cell cancer (LSCC) has not yet been investigated. This study aimed to explore the prognostic significance of immune scores and construct a clinical nomogram to predict the survival of patients with LSCC.

Methods

The clinicopathological characteristics and immune scores of 102 patients with LSCC were obtained from TCGA database and a nomogram was developed. C-index and calibration curves were applied to assess the performance of the model.

Results

Patients with higher immune scores had significantly better overall survival (OS). The prognostic nomogram presented a good performance in survival prediction.

Conclusions

High immune scores are correlated with improved OS in patients with LSCC. In addition, the nomogram developed for this study may assist clinicians in the prognostic evaluation of patients with LSCC.

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Abbreviations

LSCC:

Laryngeal squamous cell cancer

TCGA:

The Cancer Genome Atlas

OS:

Overall survival

ESTIMATE:

Estimation of STromal and Immune cells in Malignant Tumors using Expression data

HNSCC:

Head and neck squamous cell cancer

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Funding

This work was supported by the Special Financial Project of Fujian Province [Grant numbers: 2019B022]; Minimally Invasive Medical Fund of Fujian Province [Grant numbers: 2104519#]; Medical Innovation Project of Fujian Province [Grant numbers: 2017-CX-23].

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Author notes

  1. Lianming Liao and Wei Chen authors contributed equally to this work.

Authors and Affiliations

  1. Department of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China

    Lianming Liao

  2. Department of Otolaryngology, Fujian Medical University Union Hospital, 29# Xinquan Road, Fuzhou, 350001, Fujian, China

    Wei Chen, Haichun Lai, Xuehan Yi & Desheng Wang

Authors
  1. Lianming Liao
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  2. Wei Chen
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  3. Haichun Lai
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Contributions

LLM, CW and WDS performed the conception and design of this manuscript. WDS and LLM provided useful suggestions in methodology. CW, LHC and YXH performed data analysis and prepared the figure. CW and LLM drafted the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Desheng Wang.

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Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

All the data used was open access and approved with the ethics approval of The National Cancer Institute’s (NCI) Genomic Data Commons (GDC) policy.

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Not Applicable.

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Liao, L., Chen, W., Lai, H. et al. Prognostic nomogram based on immune scores for laryngeal squamous cell cancer. Eur Arch Otorhinolaryngol 278, 141–148 (2021). https://doi.org/10.1007/s00405-020-06189-z

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  • DOI: https://doi.org/10.1007/s00405-020-06189-z

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