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The role of CD133 expression of cancer stem cells on radiotherapy response in early stage glottic cancers

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the relationship between CD133 positivity and radiotherapy (RT) response in early stage glottic laryngeal cancers.

Methods

Thirty seven patients with early-stage glottic laryngeal carcinoma who were treated with primary RT were evaluated. Patients with regular follow-up of at least 3 years were included in the study. Patients who had previously received chemotherapy for laryngeal surgery or underwent surgery were excluded. The patients were divided into two groups as recurrent and non-recurrent. These two groups were compared in terms of CD133 expression by immunohistochemical method.

Results

There were 37 patients in the study. Ten patients had recurrence and seven (70%) had CD133 positive and three had CD133 negative. Of 27 patients who had no recurrence, 16 (59%) had CD133 positive and 11 (41%) had CD133 negative. 7 (70%) of ten patients with recurrence were found to be positive for CD133; There was no statistically significant difference between recurrent and non-recurrent patient groups in terms of CD133 positivity (p > 0.05). There was no correlation between the final CD133 score and recurrence status as well (p > 0.05).

Conclusion

There was no relationship between radiotherapy response and CD133 staining in early-stage glottic laryngeal cancers. It is the largest study about CD133 and RT sensitivity in early stage glottic carcinomas.

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Data availability

The datasets during and/or analyzed during the current study available from the corresponding author on reasonable request.

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Funding

This study was financed by Erciyes University, Supporting Center of Scientific Researches (Project Number: TTU 2015-6214).

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Authors and Affiliations

  1. Department of Otolaryngology, Elazığ Fethi Sekin City Hospital, Elâzığ, Turkey

    Emrah Gülmez

  2. Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Imdat Yüce, Kerem Kökoğlu, Alperen Vural & Sedat Çağlı

  3. Department of Radiation Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Mete Gündoğ

  4. Department of Pathology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Özlem Canöz

Authors
  1. Emrah Gülmez
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  2. Imdat Yüce
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  3. Mete Gündoğ
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  4. Özlem Canöz
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  5. Kerem Kökoğlu
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  6. Alperen Vural
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  7. Sedat Çağlı
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Contributions

Design, collection of data, writing: EG, KK, AV. Last control, supervisor: IY, SÇ. Statistical analysis, writing: MG. Evaluation of CD133 Score: ÖC.

Corresponding author

Correspondence to Kerem Kökoğlu.

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Conflict of interest

The authors declare no commercial or conflict of interest.

Ethics approval

This study was approved by Erciyes University, Ethical Committee of Clinical Researches, Decision Number: 2015/77.

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Because of its retrospective nature, it was not needed.

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The authors transferred all their rights to Springer for publication.

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Gülmez, E., Yüce, I., Gündoğ, M. et al. The role of CD133 expression of cancer stem cells on radiotherapy response in early stage glottic cancers. Eur Arch Otorhinolaryngol 277, 3121–3126 (2020). https://doi.org/10.1007/s00405-020-06106-4

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  • DOI: https://doi.org/10.1007/s00405-020-06106-4

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