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Factors implicated in response to treatment/prognosis of vestibular migraine

Abstract

Purpose

To identify patient factors that influence response to therapy in patients with vestibular migraines.

Methods

A retrospective cohort study was performed at a university-based tertiary medical center. Patients: 47 patients evaluated for treatment of definite vestibular migraine, per the Barany Society criteria, from 2015 to 2019. Interventions: A protocol of antidepressants, antiepileptics, beta blockers, and vestibular rehabilitation. Patients failing initial therapy received botulinum toxin per the PREEMPT protocol. Vestibular rehabilitation for motion desensitization in case of known vestibular dysfunction. Outcome measures: Quality of life measured per the dizziness handicap inventory (DHI). Pre- and post-treatment DHI scores (total and domain scores) and change in DHI were correlated against patient-specific variables to determine factors associated with change in response to therapy. Patient factors included demographic variables, medical comorbidities, comorbid otologic or pain symptoms, treatment modality, and initial DHI scores.

Results

47 patients underwent therapy for vestibular migraine. This population had a significant DHI reduction of 17.3 ± 25.2 (p < 0.001) with therapy. Univariate analysis showed that female gender, comorbid benign paroxysmal positional vertigo, and high initial DHI were significantly associated with greater reduction in DHI scores (ß = − 7.92, p = 0.033; ß = − 18.65, p = 0.028; ß = − 0.458, p = 0.016, respectively). Conversely, cervicalgia and oscillopsia were significantly associated with a lower reduction in DHI scores (ß = 5.525, p = 0.024 and ß = 21.48, p = 0.027, respectively).

Conclusions

Vestibular migraine is a complex disorder with heterogeneous response to therapy. This study shows that patient-specific factors of gender, cervicalgia, oscillopsia, BPPV, and high DHI scores on presentation may influence response to common vestibular migraine therapy.

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Authors

Contributions

JRD: participated in the analysis and interpretation of data; participated in the development and revision of the research manuscript. YFL: participated in the analysis and interpretation of data; participated in the development and revision of the research manuscript. LD: participated in the analysis and interpretation of data; participated in the development and revision of the research manuscript. HGR: participated in the analysis and interpretation of data; participated in the development and revision of the research manuscript.

Corresponding author

Correspondence to Habib G. Rizk.

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The authors declare that they have no conflict of interest.

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All procedures or data collection involving human subjects were performed in accordance with the ethical standards of the institution or practice at which the studies were conducted (Medical University of South Carolina Institutional Review Board, IRB number Pro00050097).

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Dornhoffer, J.R., Liu, Y.F., Donaldson, L. et al. Factors implicated in response to treatment/prognosis of vestibular migraine. Eur Arch Otorhinolaryngol 278, 57–66 (2021). https://doi.org/10.1007/s00405-020-06061-0

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Keywords

  • Vestibular migraine
  • Dizziness handicap inventory
  • Outcomes
  • Demographics