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Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media



To explore the rule of extended high-frequency (EHF) audiometry recovery in patients with acute otitis media.


From January 2016 to July 2019, patients with acute otitis media in the outpatient department of otology were studied. The diagnosis was made according to the otoscopy and acoustic impedance tests, and antibiotics and other treatment programs were given. The patients were followed up to compare the effects of different recovery time on extended high-frequency audiometry in patients with acute otitis media.


146 patients with acute otitis media (69 in the left ear and 77 in the right ear) were selected for observation and follow-up. The patients were divided into three groups according to the time from the onset to the disappearance of hyperacusis and earache symptoms: ≤ 5 days group (26 patients, 17.8%), 6–10 days group (74 patients, 50.7%), and > 10 days group (46 patients, 31.5%). The threshold of EHF in the study group was significantly higher than that in the control group in the early stage. According to the study design for follow-up, we found that with the prolongation of the duration of acute otitis media, the extended high frequency of different groups had different changes.


Our results show that the recovery time of EHF in patients with acute otitis media was later than that of the standard audiogram and was closely related to the course of the disease. This is of great significance for discovering the hidden hearing loss of the patients and taking the treatment plan as soon as possible.

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Data availability

All data generated or analysed during this study are included in this published article.


  1. 1.

    American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media (2004) Diagnosis and management of acute otitis media. Pediatrics 113:1451–1465

    Article  Google Scholar 

  2. 2.

    Monasta L, Ronfani L, Marchetti F, Montico M, Vecchi BL, Bavcar A, Grasso D, Barbiero C, Tamburlini G (2012) Burden of disease caused by otitis media: systematic review and global estimates. PLoS ONE 7:e36226

    CAS  Article  Google Scholar 

  3. 3.

    Vergison A, Dagan R, Arguedas A, Bonhoeffer J, Cohen R, Dhooge I, Hoberman A, Liese J, Marchisio P, Palmu AA et al (2010) Otitis media and its consequences: beyond the earache. Lancet Infect Dis 10:195–203

    Article  Google Scholar 

  4. 4.

    Mutlu C, Odabasi AO, Metin K, Basak S, Erpek G (1998) Sensorineural hearing loss associated with otitis media with effusion in children. Int J Pediatr Otorhinolaryngol 46:179–184

    CAS  Article  Google Scholar 

  5. 5.

    Gravel JS, Wallace IF (2000) Effects of otitis media with effusion on hearing in the first 3 years of life. J Speech Lang Hear Res 43:631–644

    CAS  Article  Google Scholar 

  6. 6.

    Margolis RH, Hunter LL (1991) Audiologic evaluation of the otitis media patient. Otolaryngol Clin North Am 24:877–899

    CAS  PubMed  Google Scholar 

  7. 7.

    Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF (2011) Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep 11:78–84

    Article  Google Scholar 

  8. 8.

    Kumar P, Upadhyay P, Kumar A, Kumar S, Singh GB (2017) Extended high frequency audiometry in users of personal listening devices. Am J Otolaryngol 38:163–167

    Article  Google Scholar 

  9. 9.

    Rodriguez VA, Roldan FA, Villarreal IM, Garcia BJ (2016) Extended high-frequency audiometry (9000–20,000 Hz). Usefulness in audiological diagnosis. Acta Otorrinolaringol Esp 67:40–44

    Article  Google Scholar 

  10. 10.

    Brannstrom KJ, Karlsson E, Waechter S, Kastberg T (2018) Extended high-frequency pure tone hearing thresholds and core executive functions. Int J Audiol 57:639–645

    Article  Google Scholar 

  11. 11.

    Kucur C, Kucur SK, Gozukara I, Seven A, Yuksel KB, Keskin N, Oghan F (2013) Extended high frequency audiometry in polycystic ovary syndrome. Sci World J 2013:482689

    Article  Google Scholar 

  12. 12.

    Lasso DLVM, Villarreal IM, Lopez MJ, Garcia-Berrocal JR (2017) Extended high frequency audiometry can diagnose sub-clinic involvement in a seemingly normal hearing systemic lupus erythematosus population. Acta Otolaryngol 137:161–166

    Article  Google Scholar 

  13. 13.

    Lasso DLVM, Villarreal IM, Lopez-Moya J, Garcia-Berrocal JR (2016) Examination of hearing in a rheumatoid arthritis population: role of extended-high-frequency audiometry in the diagnosis of subclinical involvement. Scientifica (Cairo) 2016:5713283

    Google Scholar 

  14. 14.

    Da CMR, Erdil M, Pauna HF, Kwon G, Schachern PA, Tsuprun V, Paparella MM, Cureoglu S (2016) Pathologic changes of the peripheral vestibular system secondary to chronic otitis media. Otolaryngol Head Neck Surg 155:494–500

    Article  Google Scholar 

  15. 15.

    Penido NO, Chandrasekhar SS, Borin A, Maranhao AS, Gurgel TJ (2016) Complications of otitis media—a potentially lethal problem still present. Braz J Otorhinolaryngol 82:253–262

    Article  Google Scholar 

  16. 16.

    Park JH, Park SJ, Kim YH, Park MH (2014) Sensorineural hearing loss: a complication of acute otitis media in adults. Eur Arch Otorhinolaryngol 271:1879–1884

    Article  Google Scholar 

  17. 17.

    Cordeiro FP, Da CMR, Kasemodel A, de Almeida GL, de Oliveira PN (2018) Extended high-frequency hearing loss following the first episode of otitis media. Laryngoscope 128:2879–2884

    Article  Google Scholar 

  18. 18.

    Basch ML, Brown RN, Jen HI, Groves AK (2016) Where hearing starts: the development of the mammalian cochlea. J Anat 228:233–254

    Article  Google Scholar 

  19. 19.

    Kelly MC, Chen P (2009) Development of form and function in the mammalian cochlea. Curr Opin Neurobiol 19:395–401

    CAS  Article  Google Scholar 

  20. 20.

    Ren T, He W, Kemp D (2016) Reticular lamina and basilar membrane vibrations in living mouse cochleae. Proc Natl Acad Sci USA 113:9910–9915

    CAS  Article  Google Scholar 

  21. 21.

    Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD et al (2013) The diagnosis and management of acute otitis media. Pediatrics 131:e964–e999

    Article  Google Scholar 

  22. 22.

    Da CS, Rosito LP, Dornelles C (2009) Sensorineural hearing loss in patients with chronic otitis media. Eur Arch Otorhinolaryngol 266:221–224

    Article  Google Scholar 

  23. 23.

    Ali ZS, Pasha HA, Suhail A, Qureshi TA (2016) Frequency of Sensorineural hearing loss in chronic suppurative otitis media. J Pak Med Assoc 66(Suppl 3):S42–S44

    Google Scholar 

  24. 24.

    Amali A, Hosseinzadeh N, Samadi S, Nasiri S, Zebardast J (2017) Sensorineural hearing loss in patients with chronic suppurative otitis media: is there a significant correlation? Electron Phys 9:3823–3827

    Article  Google Scholar 

  25. 25.

    Suaya JA, Gessner BD, Fung S, Vuocolo S, Scaife J, Swerdlow DL, Isturiz RE, Arguedas AG (2018) Acute otitis media, antimicrobial prescriptions, and medical expenses among children in the United States during 2011–2016. Vaccine 36:7479–7486

    Article  Google Scholar 

  26. 26.

    Mustafa G, Al AA, Al AI, Meszaros K, Gopala K, Ceyhan M, Al-Tannir M, DeAntonio R, Bawikar S, Schmidt JE (2017) Incidence and economic burden of acute otitis media in children aged up to 5years in three Middle Eastern countries and Pakistan: a multinational, retrospective, observational study. J Epidemiol Glob Health 7:123–130

    Article  Google Scholar 

  27. 27.

    Salt AN, Hirose K (2018) Communication pathways to and from the inner ear and their contributions to drug delivery. Hear Res 362:25–37

    CAS  Article  Google Scholar 

  28. 28.

    Hellstrom S, Eriksson PO, Yoon YJ, Johansson U (1997) Interactions between the middle ear and the inner ear: bacterial products. Ann NY Acad Sci 830:110–119

    CAS  Article  Google Scholar 

  29. 29.

    Juhn SK, Hamaguchi Y, Goycoolea M (1989) Review of round window membrane permeability. Acta Otolaryngol Suppl 457:43–48

    CAS  PubMed  Google Scholar 

  30. 30.

    Kasemodel ALP, Costa LEM, Monsanto RDC, Tomaz A, Penido NO (2019) Sensorineural hearing loss in the acute phase of a single episode of acute otitis media. Braz J Otorhinolaryngol.

    Article  PubMed  Google Scholar 

  31. 31.

    Sharma D, Munjal SK, Panda NK (2012) Extended high frequency audiometry in secretory otitis media. Indian J Otolaryngol Head Neck Surg 64:145–149

    Article  Google Scholar 

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This work was supported by funding from the National Natural Science Foundation of China (81802825) and Shanxi Provincial People’s Hospital (17160). Innovative Research Group Project of the National Natural Science Foundation of China.

Author information




Data curation: Lu Sun; formal analysis: Lu Sun; investigation: Guodong Li and Lu Sun; methodology: Guodong Li and Lu Sun; project administration: Tongli Li and Hong Liu; resources: Guodong Li, Lu Sun, and Hong Liu; supervision: Tongli Li and Hong Liu; writing original draft: Guodong Li; writing review and editing: Hong Liu.

Corresponding author

Correspondence to Hong Liu.

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The authors declare that they have no competing financial interests.

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All samples’ experiments were approved by the ethics committee. All samples were obtained before treatment according to the guidelines of the local ethics committees and written informed consents were received from all participants.

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Written informed consent for publication was obtained from all participants.

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Li, G., Li, T., Liu, H. et al. Correlation between recovery time of extended high-frequency audiometry and duration of inflammation in patients with acute otitis media. Eur Arch Otorhinolaryngol 277, 2447–2453 (2020).

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  • Extended high frequency
  • Acute otitis media
  • Inflammation
  • Hyperacusis