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Odontogenic tumours: a 25-year epidemiological study in the Marche region of Italy

  • Head and Neck
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Epidemiological data of odontogenic tumours (OT) are conflicting, with significant differences among the countries. This study aims to evaluate incidence and prevalence of OTs in the Marche population in a period of 25 years, according to 4th Edition of WHO Classification.


In this study, only patients of Marche region treated for OTs were considered. Data were retrieved from Institute of Pathology, Marche Polytechnic University, Italy. Because this is the only tertiary referral centre for Head and Neck pathology within Marche region, the patient sample could be considered well representative of this area. From each case, age, sex, site, diagnosis and relapses were recorded.


Overall, 100 patients were treated for OTs from 1994 to 2018 in Marche region. The annual incidence rate ranged from 0.13 to 0.39 per 100,000, while life prevalence was 6.50 per 100,000. Mean age of onset for primary OTs was 49.7 ± 20.1 years. Twenty-seven patients developed recurrences, showing a mean age of 54 ± 19.7 years and a mean recurrence time of 51.2 ± 34 months.


This is the first epidemiological study on OTs in Italian population according to 4th Edition of WHO Classification. Although limited in their retrospective nature, these findings could accurately estimate epidemiology of OTs in Italy.

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Authors and Affiliations



Conceptualization: MM, LLM, AS; methodology: LT, GT, VCAC; formal analysis and investigation: CR, GT, VCAC; writing—original draft preparation: MM, LT, AB; writing—review and editing: AS; supervision: LLM, AS, CR. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Marco Mascitti.

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The authors declare that they have no conflicts of interest.

Ethical approval

The study was conducted in accordance with the “Ethical Principles for Medical Research Involving Human Subjects” statement of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Research involving human participant and animal rights

This study received exemption from the institutional review board, because of its retrospective nature. This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Electronic supplementary material

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Supplementary Table

 1: Average yearly population in Marche region for the period 1994–2018, reported by the Italian National Institute of Statistics (ISTAT). (XLSX 20 kb)

Supplementary Table

 2: Annual incidence rate of odontogenic tumours in Marche population (1994–2018). (XLSX 16 kb)

Supplementary Table

 3: Clinical and pathological data of OTs in paediatric patients of Marche population (1994–2018). (DOCX 15 kb)

Supplementary Table

 4: Clinical and pathological data of OTs in geriatric patients of Marche population (1994–2018). (DOCX 16 kb)

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Mascitti, M., Togni, L., Troiano, G. et al. Odontogenic tumours: a 25-year epidemiological study in the Marche region of Italy. Eur Arch Otorhinolaryngol 277, 527–538 (2020).

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