Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere’s disease: our results



Specially processed cereals (SPC) that increase endogenous antisecretory factor (AF) synthesis have been proposed to improve symptoms of Meniere’s disease (MD) with controversial results. The aim of this study was to evaluate the effects of SPC in patients with definite unilateral MD and compare the results to a treatment protocol with intravenous glycerol and dexamethasone.


Thirteen patients with unilateral MD were treated with SPC and 13 patients were treated with intravenous glycerol and dexamethasone for 12 months. Audio-vestibular evaluation was performed before (T0) and at the end of the treatments (T12). The number of vertigo spells were evaluated before and after therapy and the Efficacy Index (EI) was calculated. Questionnaires for hearing loss (HHIA), tinnitus (THI) and quality of life (TFL) were administered.


EI decreased in the SPC group in the second semester compared to the first although not significantly (p = 0.6323). There was a significant reduction for THI score in the SPC group at T12 (p = 0.0325). No significant differences were found between the two groups at T0 (p = 0.4723), while a significant difference was found at T12 (p = 0.0041). Quality of life showed an improvement in daily activities in the SPC group compared to infusion therapy group.


Our study shows a reduced number of vertigo attacks and a positive effect on the discomfort generated by tinnitus and quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.

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Correspondence to Massimo Ralli.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee of the University of Naples ‘‘Federico II” (2017) and the University of Salerno (2018) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Scarpa, A., Ralli, M., Viola, P. et al. Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere’s disease: our results. Eur Arch Otorhinolaryngol 277, 77–83 (2020).

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  • Meniere’s disease
  • Specially processed cereals
  • Endogenous antisecretory factor
  • Vertigo
  • Hearing loss