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Clinical significance of cervical and ocular vestibular evoked myogenic potentials in benign paroxysmal positional vertigo: a meta-analysis

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Abstract

Purpose

As the pathological cause of benign paroxysmal positional vertigo (BPPV), the dislocation or degeneration of otoconia in the utricle and saccule is suggested. Vestibular evoked myogenic potential (VEMP) could reflect otolithic dysfunction due to these etiologies of BPPV. The aim of this study was to validate the clinical significance of cervical (c) and ocular (o) VEMP in BPPV by a meta-analysis of previous articles.

Methods

Articles related to BPPV with data on cVEMP and oVEMP were collected. The following keywords were used to search PubMed and Scopus for English language articles: benign paroxysmal positional vertigo or BPPV and vestibular evoked myogenic potential or VEMP.

Results

The p13 latency in cVEMP and n1 latency in oVEMP were slightly but significantly prolonged in BPPV patients compared to control patients. AR in oVEMP of BPPV patients also showed higher value than that of control patients. However, the n23 latency and AR in cVEMP and p1 latency in oVEMP showed no significant difference between BPPV and control patients. Furthermore, latencies in VEMPs also showed no significant difference between an affected and a non-affected ear in BPPV patients.

Conclusions

Our results indicated that otolith dysfunction of BPPVs was detected by latencies in VEMPs, and AR in oVEMP more sensitively reflects the difference between affected and non-affected ears in BPPV patients. The otolith dysfunction of BPPV might be induced by the systemic condition. However, the differences of latencies between BPPV patients and control patients were too small to use VEMPs as a prognostic predictor.

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Acknowledgements

The authors would like to thank Enago (www.enago.jp) for the English language review.

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Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, Japan

    Ryohei Oya, Takao Imai, Takashi Sato, Kazuo Oshima, Yumi Ohta & Hidenori Inohara

  2. Department of Otorhinolaryngology Head and Neck Surgery, Kansai Medical Hospital, 1-7-2 Shinsenrinishimachi, Toyonaka, Osaka, Japan

    Yukinori Takenaka

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  1. Ryohei Oya
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  2. Takao Imai
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  3. Yukinori Takenaka
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  7. Hidenori Inohara
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Contributions

RO conceived and designed the study and wrote the paper. RO, TI, and YT collected and analyzed the data. TS, KO, YO, and HI reviewed and revised the manuscript.

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Correspondence to Ryohei Oya.

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Oya, R., Imai, T., Takenaka, Y. et al. Clinical significance of cervical and ocular vestibular evoked myogenic potentials in benign paroxysmal positional vertigo: a meta-analysis. Eur Arch Otorhinolaryngol 276, 3257–3265 (2019). https://doi.org/10.1007/s00405-019-05674-4

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