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Comparing the effect of dexmedetomidine and labetalol on hemodynamic variables in patients undergoing microlaryngoscopy

  • Laryngology
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Introduction

This study was conducted to compare the effect of dexmedetomidine and labetalol on hemodynamic variables in patients undergoing microlaryngoscopy.

Material and methods

In this randomized clinical trial study 70 patients undergoing microlaryngoscopy were involved. The patients were randomly assigned into two groups. Patients in dexmedetomidine group received 0.5 μg/kg of dexmedetomidine diluted in 100 ml of saline solution and the patients in the second group received 0.25 mg/kg of labetalol before anesthesia induction. At the beginning of the surgery, dexmedetomidine was infused at the dose of 0.4 μg/kg/h in the dexmedetomidine group, and labetalol at the dose of 1.8 mg/kg/h in the labetalol group. Patients’ systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and heart rate at different times and anesthesia and surgery duration, recovery time and dose of prescribed propofol were recorded and compared between two groups.

Results

There was a significant difference in mean systolic blood pressure, mean diastolic blood pressure, mean arterial blood pressure and mean heart rate between two groups at different times (p value < 0.05).

Conclusion

The results of this study indicated that dexmedetomidine had higher efficacy, compared to labetalol, in reducing diastolic blood pressure, systolic blood pressure, heart rate, and mean arterial blood pressure following microlaryngoscopy.

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Authors and Affiliations

  1. Departments of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Maryam Hatami, Maryam Mashayekhi, Hamidreza Abbasi & Vida Ayatollahi

  2. Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Sedighe Vaziribozorg

Authors
  1. Maryam Hatami
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  2. Maryam Mashayekhi
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  3. Hamidreza Abbasi
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  4. Vida Ayatollahi
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  5. Sedighe Vaziribozorg
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Corresponding author

Correspondence to Sedighe Vaziribozorg.

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Authors have no conflicts of interest.

Ethical approval

Study protocol was in accordance with the latest Declaration of Helsinki for medical research involving human subjects and was approved by ethics committee of Shahid Sadoughi University of Medical Sciences.

Research involving animals

This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all participants of the study.

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Hatami, M., Mashayekhi, M., Abbasi, H. et al. Comparing the effect of dexmedetomidine and labetalol on hemodynamic variables in patients undergoing microlaryngoscopy. Eur Arch Otorhinolaryngol 276, 2513–2517 (2019). https://doi.org/10.1007/s00405-019-05521-6

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  • DOI: https://doi.org/10.1007/s00405-019-05521-6

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