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Peritonsillar dexamethasone–bupivacaine vs. bupivacaine infiltration for post-tonsillectomy pain relief in children: a randomized, double-blind, controlled study

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Abstract

Objective

Post-tonsillectomy pain is one of the most frequent morbidities of tonsillectomy surgery. Currently, there is no standard protocol for post-tonsillectomy pain control. In our study, we aimed to compare the effects of perioperative peritonsillar dexamethasone–bupivacaine and bupivacaine-alone infiltration on pain control in pediatric patients.

Materials and methods

This prospective, randomized, double-blind, controlled clinical trial was conducted between February 2018 and May 2018 in a single-center tertiary education and research hospital, otorhinolaryngology/head and neck surgery clinic, under general anesthesia, which included 120 pediatric patients between the ages of 2–12 (mean 5.7 ± 1.8), and who were with ASA (American Society of Anesthesiologists) I–II classification. Patients were randomly divided into three groups as 40 participants in each group. Group 1 consisted of patients who were injected with dexamethasone–bupivacaine into their peritonsillar region, group 2 consisted of patients who were injected with bupivacaine only, and group 3 consisted of patients who were injected with saline only as the control group. FLACC (face, legs, activity, cry, consolability) Scale and Wong-Baker FACES® Pain Rating Scale (WBS) were used for early and late period postoperative pain scoring. Patients with pain score ≥ 4 were treated with paracetamol rescue analgesia. Side effects such as nausea, vomiting and bleeding were recorded. Data of all groups were compared statistically and p ≤ 0.05 was considered statistically significant.

Results

There was no significant difference between the groups in terms of demographic data, duration of operation and duration of anesthesia. The pain scores of group 1 were significantly lower than those of the control group except for postoperative 45th min, 2nd day and 3rd day. The pain scores of the group 1 were significantly lower at all times except for the postoperative 12th and 24th hour, than those of group 2. The pain scores of the group 2 were lower than the control group only at postoperative 7th day, but no significant difference was found at other times. No statistically significant difference was found between the groups in terms of requirement rates for the first 60 min recovery analgesia (p = 0.686). No statistical difference was found between the groups in terms of side effects.

Conclusion

In our study, preoperative local dexamethasone–bupivacaine infiltration in pediatric patients was shown to be more effective than bupivacaine-only and serum-only infiltration for early and late post-tonsillectomy pain control.

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Acknowledgements

This study was carried out in Sisli Hamidiye Etfal Training and Research Hospital, Istanbul.

Funding

There are no financial conflicts of interest to disclose.

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Authors and Affiliations

  1. Anesthesiology and Reanimation Department, Sisli Hamidiye Etfal Training and Research Hospital, Halaskargazi Cad. Etfal Sok, 34377, Sisli/Istanbul, Turkey

    Leyla Kilinc, Hacer S. Türk, Surhan Cinar & Serkan İslamoğlu

  2. Otorhinolaryngology Head and Neck Surgery Department, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

    Bilge Türk & Suat Turgut

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  1. Leyla Kilinc
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Correspondence to Hacer S. Türk.

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Kilinc, L., Türk, B., Türk, H.S. et al. Peritonsillar dexamethasone–bupivacaine vs. bupivacaine infiltration for post-tonsillectomy pain relief in children: a randomized, double-blind, controlled study. Eur Arch Otorhinolaryngol 276, 2081–2089 (2019). https://doi.org/10.1007/s00405-019-05472-y

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