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Olfactory dysfunction in spondyloarthritis

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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

Spondyloarthritis (SpA) is a group of disorders characterized by inflammatory arthritis including ankylosing spondylitis, psoriatic arthritis, reactive arthritis and arthritis-related inflammatory bowel diseases. Recently it has been shown that arthritic disorders are accompanied by olfactory dysfunction. We aimed to specifically investigate the association between spondyloarthritis and olfactory impairment.

Materials and methods

Fifty individuals with SpA and 50 healthy volunteers were included in the study. Olfactory function was evaluated using the “Sniffin’ Sticks” test battery. Additionally, effects of age, gender, activity of the disease, HLA-B27 status, medications, and the duration of disease were included in the analysis.

Results

SpA patients showed significantly lower scores for odor threshold (T), odor discrimination (D) and odor identification (I) than healthy controls (all p < 0.001). In addition, olfactory loss was negatively correlated with the presence of HLA-B27 (Human Leukocyte Antigen), but not with the current activity of the disease (Bath Ankylosing Spondylitis Activity Index). Neither medication nor duration of the disease had a significant effect on the results.

Conclusion

SpA is associated with olfactory loss. Future studies will show whether olfactory function relates to the prognosis of SpA.

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Authors and Affiliations

  1. Otorhinolaryngology Department, Medicana International Hospital, Ankara, Turkey

    Esin Yalcinkaya & Hakan Erdem

  2. Otorhinolaryngology Department, Ufuk University, Ankara, Turkey

    Mustafa Mert Basaran

  3. Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey

    Murat Kocyigit

  4. Otorhinolaryngology Department, Acibadem Taksim Hospital, Istanbul, Turkey

    Aytug Altundag

  5. Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany

    Thomas Hummel

Authors
  1. Esin Yalcinkaya
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  2. Mustafa Mert Basaran
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  3. Hakan Erdem
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  4. Murat Kocyigit
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  5. Aytug Altundag
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  6. Thomas Hummel
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Correspondence to Thomas Hummel.

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Yalcinkaya, E., Basaran, M.M., Erdem, H. et al. Olfactory dysfunction in spondyloarthritis. Eur Arch Otorhinolaryngol 276, 1241–1245 (2019). https://doi.org/10.1007/s00405-019-05364-1

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  • DOI: https://doi.org/10.1007/s00405-019-05364-1

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