Skip to main content

Advertisement

SpringerLink
Log in

Clinical behaviours and prognoses of high- and low-risk parotid malignancies based on histology

  • Head & Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To report 5-year survival in patients with primary parotid malignant tumours and assess the impact of various factors on survival or local control among diverse histologic groups.

Methods

A total of 65 patients with primary parotid malignant tumours who had surgery between 2003 and 2014 were identified. Demographic characteristics including age, T stage, N stage and clinical or pathological performance were analysed. According to risk stratification (based on pathology), 65 primary parotid malignant tumours were divided into high-risk (23, 35.38%) and low-risk (35, 53.85%) groups. Overall survival (OS) and disease-free survival (DFS) were recorded by the Kaplan–Meier methods.

Results

The 5-year overall survival rate for primary parotid malignant tumours was 70.9%. Patients older than 60 years with fixed mass, pain, facial-nerve palsy and high-grade N stage had adverse OS and DFS. Upon multivariable analysis, facial-nerve palsy (HR 24.59; 95% CI 2.338–178.446; P = 0.002) was the only independent predictive factor for OS. Patients with high-risk parotid malignant types were more likely to have tumour pain, facial-nerve palsy (Chi-square test: < 0.0001 and 0.02), lymphatic metastasis and local/regional recurrence (Chi-square test: 0.008 and 0.012).

Conclusions

Compared with low-risk parotid carcinoma, tumours with high-risk histological features tend to need aggressive surgical extirpation, neck dissection and postoperative radiotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

OS:

Overall survival

DFS:

Disease-free survival

WHO:

World Health Organization

PPMT:

Primary parotid malignant tumour

SPMT:

Secondary parotid malignant tumour

HRs:

Hazard ratios

References

  1. Lewis AG, Tong T, Maghami E (2016) Diagnosis and management of malignant salivary gland tumors of the parotid gland. Otolaryngol Clin N Am 49(2):343–380. https://doi.org/10.1016/j.otc.2015.11.001

    Article  Google Scholar 

  2. Nam SJ, Roh JL, Cho KJ, Choi SH, Nam SY, Kim SY (2016) Risk factors and survival associated with distant metastasis in patients with carcinoma of the salivary gland. Ann Surg Oncol 23(13):4376–4383. https://doi.org/10.1245/s10434-016-5356-3

    Article  PubMed  Google Scholar 

  3. Lombardi D, McGurk M, Vander Poorten V, Guzzo M, Accorona R, Rampinelli V, Nicolai P (2017) Surgical treatment of salivary malignant tumors. Oral Oncol 65:102–113. https://doi.org/10.1016/j.oraloncology.2016.12.007

    Article  PubMed  Google Scholar 

  4. Liu Y, Su M, Yang Y, Zhao B, Qin L, Han Z (2017) Prognostic factors associated with decreased survival in patients with acinic cell carcinoma of the parotid gland. J Oral Maxillofac Surg 75(2):416–422. https://doi.org/10.1016/j.joms.2016.06.185

    Article  PubMed  Google Scholar 

  5. Bell RB, Dierks EJ, Homer L, Potter BE (2005) Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg 63(7):917–928

    Article  PubMed  Google Scholar 

  6. Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, Cernea CR, Soares JR, Santos IC, Salviano S (2005) Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg 133(5):702–708. https://doi.org/10.1016/j.otohns.2005.08.001

    Article  PubMed  Google Scholar 

  7. Seethala RR (2009) An update on grading of salivary gland carcinomas. Head neck Pathol 3(1):69–77. https://doi.org/10.1007/s12105-009-0102-9

    Article  PubMed  PubMed Central  Google Scholar 

  8. Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471–1474. https://doi.org/10.1245/s10434-010-0985-4

    Article  PubMed  Google Scholar 

  9. Rayess HM, Dezube A, Bawab I, Raza SN, Yoo GH, Lin HS, Jacobs JR (2017) Tumor differentiation as a prognostic factor for major salivary gland malignancies. Otolaryngol Head Neck Surg. https://doi.org/10.1177/0194599817700593

    Article  PubMed  Google Scholar 

  10. Walvekar RR, Filho PAA, Seethala RR, Gooding WE, Heron DE, Johnson JT, Ferris RL (2011) Clinicopathologic features as stronger prognostic factors than histology or grade in risk stratification of primary parotid malignancies. Head Neck 33(2):225–231

    Article  PubMed  PubMed Central  Google Scholar 

  11. Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Loftus-Coll BM, Keus RB, van Leeuwen FE, Hart AA (1999) The development of a prognostic score for patients with parotid carcinoma. Cancer 85(9):2057–2067

    Article  PubMed  CAS  Google Scholar 

  12. Hocwald E, Korkmaz H, Yoo GH, Adsay V, Shibuya TY, Abrams J, Jacobs JR (2001) Prognostic factors in major salivary gland cancer. Laryngoscope 111(8):1434–1439. https://doi.org/10.1097/00005537-200108000-00021

    Article  PubMed  CAS  Google Scholar 

  13. Thielker J, Grosheva M, Ihrler S, Wittig A, Guntinas-Lichius O (2018) Contemporary management of benign and malignant parotid tumors. Front Surg 5:39. https://doi.org/10.3389/fsurg.2018.00039

    Article  PubMed  PubMed Central  Google Scholar 

  14. Park GC, Roh JL, Cho KJ, Jung YG, Lee HW, Kim TG, Choi SH, Nam SY, Kim SY (2018) Survival outcome of intermediate-grade salivary gland carcinoma. Oncology 94(2):125–132. https://doi.org/10.1159/000484411

    Article  PubMed  Google Scholar 

  15. Son E, Panwar A, Mosher CH, Lydiatt D (2018) Cancers of the major salivary gland. J Oncol Pract 14(2):99–108. https://doi.org/10.1200/JOP.2017.026856

    Article  PubMed  Google Scholar 

  16. Ramirez-Perez F, Gonzalez-Garcia R, Hernandez-Vila C, Monje-Gil F, Ruiz-Laza L (2017) Is fine-needle aspiration a reliable tool in the diagnosis of malignant salivary gland tumors? J Cranio-Maxillo-fac Surg 45 (7):1074–1077. https://doi.org/10.1016/j.jcms.2017.03.019

    Article  Google Scholar 

  17. Cracchiolo JR, Shaha AR (2016) Parotidectomy for parotid cancer. Otolaryngol Clin N Am 49(2):415–424. https://doi.org/10.1016/j.otc.2015.10.007

    Article  Google Scholar 

Download references

Author information

Author notes

  1. Lei Tao and Duo Zhang: co-first authors.

Authors and Affiliations

  1. Department of Otolaryngology-HNS, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University School of Medicine, 83 Fenyang Road, Shanghai, 200031, China

    Lei Tao, Duo Zhang, Ming Zhang & Liang Zhou

  2. Department of Pudong Hospital, Fudan University School of Medicine, 2800 Gongwei Road, Shanghai, 201300, China

    Lei Tao, Duo Zhang, Ming Zhang & Liang Zhou

Authors
  1. Lei Tao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Duo Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ming Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liang Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Liang Zhou.

Ethics declarations

Conflict of interest

The authors have no conflict of interest concerning the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of Eye & ENT Hospital of Fudan University and with the 1964 Helsinki Declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tao, L., Zhang, D., Zhang, M. et al. Clinical behaviours and prognoses of high- and low-risk parotid malignancies based on histology. Eur Arch Otorhinolaryngol 276, 497–503 (2019). https://doi.org/10.1007/s00405-018-5224-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-018-5224-9

Keywords

Search

Navigation