Olfactory function and olfactory bulb volume in Wilson’s disease



To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson’s Disease (WD) patients.


A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.


There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05).


WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.

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This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

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Correspondence to Nazan Degirmenci.

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The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

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Informed consent was obtained from all individual participants included in the study.

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Degirmenci, N., Veyseller, B., Hanagasi, H. et al. Olfactory function and olfactory bulb volume in Wilson’s disease. Eur Arch Otorhinolaryngol 276, 139–142 (2019). https://doi.org/10.1007/s00405-018-5216-9

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  • Wilson’s disease
  • Olfactory dysfunction
  • Olfactory bulb
  • Olfaction