Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?
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In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis.
Materials and methods
Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically.
The histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p < 0.002) and median thickness of the TMs (p < 0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p < 0.002).
Oral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.
KeywordsAntioxidants Myringosclerosis Montelukast Tympanic membrane
The authors are grateful to Dr. Gülin Gökçe Kesici (Yıldırım Beyazıt University, Atatürk Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey) for statistical analysis of data for her help during the experiment.
There is no financing in this study.
Compliance with ethical standards
Conflict of interest
There is no conflict of interest in this study.
The experimental study complied with experimental ethical principles and animal protection laws according to the rules and regulations in Turkey, approved by the Local Ethics Committee in Ankara, Turkey (Prot. no: 01/03/2018-0045). This study was conducted in compliance with the guidelines for animal experimentation at the Department of Laboratory Animal Science of Medical School.
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