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Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objectives

In this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis.

Materials and methods

Twenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically.

Results

The histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p < 0.002) and median thickness of the TMs (p < 0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p < 0.002).

Conclusion

Oral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.

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Acknowledgements

The authors are grateful to Dr. Gülin Gökçe Kesici (Yıldırım Beyazıt University, Atatürk Education and Research Hospital, Otolaryngology Clinic, Ankara, Turkey) for statistical analysis of data for her help during the experiment.

Funding

There is no financing in this study.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey

    Selda Kargin Kaytez, Ali Kavuzlu, Ramazan Oçal & Ozlem Akkoca

  2. Department of Pathology, Harran University, Faculty of Veterinary Medicine, Şanliurfa, Turkey

    Nihat Yumusak

Authors
  1. Selda Kargin Kaytez
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  2. Ali Kavuzlu
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  3. Nihat Yumusak
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Conflict of interest

There is no conflict of interest in this study.

Ethical approval

The experimental study complied with experimental ethical principles and animal protection laws according to the rules and regulations in Turkey, approved by the Local Ethics Committee in Ankara, Turkey (Prot. no: 01/03/2018-0045). This study was conducted in compliance with the guidelines for animal experimentation at the Department of Laboratory Animal Science of Medical School.

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Kargin Kaytez, S., Kavuzlu, A., Yumusak, N. et al. Is there any effect of montelukast on prevention of myringosclerosis after myringotomy in a rat model?. Eur Arch Otorhinolaryngol 276, 57–62 (2019). https://doi.org/10.1007/s00405-018-5181-3

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  • DOI: https://doi.org/10.1007/s00405-018-5181-3

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