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Soft palate cephalometric changes with a mandibular advancement device may be associated with polysomnographic improvement in obstructive sleep apnea

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

It is unclear whether soft palate-associated changes in cephalometry associated with a mandibular advancement device (MAD) are independently associated with improvements in polysomnography (PSG) respiratory parameters in obstructive sleep apnea (OSA).

Methods

This retrospective review aimed to identify the association between soft palate-associated changes in cephalometry and PSG changes after application of an MAD. Korean patients diagnosed with OSA who underwent cephalometry with or without an MAD were enrolled. All the patients were evaluated after undergoing full-night PSG twice: once with an MAD and once without. Cephalometric findings were measured using an image analyzer.

Results

Mean apnea–hypopnea index significantly decreased with an MAD from 36.4/h to 14.7/h (p < 0.001). Retropalatal airway space significantly increased with an MAD from 6.6 to 7.3 mm (p = 0.013). Soft palate length also significantly decreased with an MAD from 43.6 to 42.3 mm (p = 0.02). Although these findings were shown by responders (patients with a reduction of apnea–hypopnea index by more than 50%), there were no significant changes in non-responders. However, retroglossal airway space did not significantly increase with an MAD even in responders.

Conclusions

Improvement of OSA with an MAD can be predicted with soft palate-associated upper airway changes shown in cephalometry.

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References

  1. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V (2005) Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353:2034–2041

    Article  PubMed  CAS  Google Scholar 

  2. Jean-Louis G, Zizi F, Brown D, Ogedegbe G, Borer J, McFarlane S (2009) Obstructive sleep apnea and cardiovascular disease: evidence and underlying mechanisms. Minerva Pneumol 48:277–293

    PubMed  PubMed Central  CAS  Google Scholar 

  3. Alam I, Lewis K, Stephens JW, Baxter JN (2007) Obesity, metabolic syndrome and sleep apnoea: all pro-inflammatory states. Obes Rev 8:119–127

    Article  PubMed  CAS  Google Scholar 

  4. Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, Chesson AL Jr, Friedman L, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ, Standards of Practice Committee of the A, American Academy of Sleep M (2008) Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of Sleep Medicine report. Sleep 31:141–147

    Article  PubMed  PubMed Central  Google Scholar 

  5. Clark GT, Blumenfeld I, Yoffe N, Peled E, Lavie P (1996) A crossover study comparing the efficacy of continuous positive airway pressure with anterior mandibular positioning devices on patients with obstructive sleep apnea. Chest 109:1477–1483

    Article  PubMed  CAS  Google Scholar 

  6. Tan YK, L’Estrange PR, Luo YM, Smith C, Grant HR, Simonds AK, Spiro SG, Battagel JM (2002) Mandibular advancement splints and continuous positive airway pressure in patients with obstructive sleep apnoea: a randomized cross-over trial. Eur J Orthod 24:239–249

    Article  PubMed  CAS  Google Scholar 

  7. Broussard DL, Altschuler SM (2000) Central integration of swallow and airway-protective reflexes. Am J Med 108:62S–67S

    Article  PubMed  Google Scholar 

  8. Gurani SF, Di Carlo G, Cattaneo PM, Thorn JJ, Pinholt EM (2016) Effect of head and tongue posture on the pharyngeal airway dimensions and morphology in three-dimensional imaging: a systematic review. J Oral Maxillofac Res 7:e1

    Article  PubMed  PubMed Central  Google Scholar 

  9. Stuck BA, Maurer JT (2008) Airway evaluation in obstructive sleep apnea. Sleep Med Rev 12:411–436

    Article  PubMed  Google Scholar 

  10. Cossellu G, Biagi R, Sarcina M, Mortellaro C, Farronato G (2015) Three-dimensional evaluation of upper airway in patients with obstructive sleep apnea syndrome during oral appliance therapy. J Craniofac Surg 26:745–748

    Article  PubMed  Google Scholar 

  11. Raunio A, Mattila P, Huuskonen U, Oikarinen K, Sandor GK (2015) The influence of a mandibular advancement plate on polysomnography in different grades of obstructive sleep apnea. J Oral Maxillofac Res 6:e4

    Article  PubMed  PubMed Central  Google Scholar 

  12. Gao XM, Zeng XL, Fu MK, Huang XZ (1999) Magnetic resonance imaging of the upper airway in obstructive sleep apnea before and after oral appliance therapy. Chin J Dent Res 2:27–35

    PubMed  CAS  Google Scholar 

  13. Lee CH, Kim JW, Lee HJ, Seo BS, Yun PY, Kim DY, Yoon IY, Rhee CS, Park JW, Mo JH (2010) Determinants of treatment outcome after use of the mandibular advancement device in patients with obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 136:677–681

    Article  PubMed  Google Scholar 

  14. Neelapu BC, Kharbanda OP, Sardana HK, Balachandran R, Sardana V, Kapoor P, Gupta A, Vasamsetti S (2017) Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: A systematic review and meta-analysis of cephalometric studies. Sleep Med Rev 31:79–90

    Article  PubMed  Google Scholar 

  15. Sharples LD, Clutterbuck-James AL, Glover MJ, Bennett MS, Chadwick R, Pittman MA, Quinnell TG (2016) Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea. Sleep Med Rev 27:108–124

    Article  PubMed  Google Scholar 

  16. Sharples L, Glover M, Clutterbuck-James A, Bennett M, Jordan J, Chadwick R, Pittman M, East C, Cameron M, Davies M, Oscroft N, Smith I, Morrell M, Fox-Rushby J, Quinnell T (2014) Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea-hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure. Health Technol Assess 18(67):1–296

    Article  PubMed  PubMed Central  Google Scholar 

  17. Vroegop AV, Vanderveken OM, Dieltjens M, Wouters K, Saldien V, Braem MJ, Van de Heyning PH (2013) Sleep endoscopy with simulation bite for prediction of oral appliance treatment outcome. J Sleep Res 22:348–355

    Article  PubMed  Google Scholar 

  18. Bastanza EDEC., Della Marca G, Grippaudo G, Rizzotto C, Marchese G, Fiorita MR, Sergi A, Meucci B, W D, Paludetti DIN, Scarano G E (2015) Drug-induced sleep endoscopy as a selection tool for mandibular advancement therapy by oral device in patients with mild to moderate obstructive sleep apnoea. Acta Otorhinolaryngol Ital 35:426–432

    PubMed  PubMed Central  Google Scholar 

  19. Lee CH, Kim JW, Lee HJ, Yun PY, Kim DY, Seo BS, Yoon IY, Mo JH (2009) An investigation of upper airway changes associated with mandibular advancement device using sleep videofluoroscopy in patients with obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 135:910–914

    Article  PubMed  Google Scholar 

  20. Okuno K, Sasao Y, Nohara K, Sakai T, Pliska BT, Lowe AA, Ryan CF, Almeida FR (2016) Endoscopy evaluation to predict oral appliance outcomes in obstructive sleep apnoea. Eur Respir J 47:1410–1419

    Article  PubMed  Google Scholar 

  21. Prescinotto R, Haddad FL, Fukuchi I, Gregorio LC, Cunali PA, Tufik S, Bittencourt LR (2015) Impact of upper airway abnormalities on the success and adherence to mandibular advancement device treatment in patients with Obstructive Sleep Apnea Syndrome. Braz J Otorhinolaryngol 81:663–670

    Article  PubMed  Google Scholar 

  22. Ardehali MM, Zarch VV, Joibari ME, Kouhi A (2016) Cephalometric assessment of upper airway effects on craniofacial morphology. J CraniofacSurg 27(2):361–364

    Article  Google Scholar 

  23. Lecomber AR, Yoneyama Y, Lovelock DJ, Hosoi T, Adams AM (2001) Comparison of patient dose from imaging protocols for dental implant planning using conventional radiography and computed tomography. Dentomaxillofac Radiol 30(5):255–259

    Article  PubMed  CAS  Google Scholar 

  24. Alessandri-Bonetti G, Ippolito DR, Bartolucci ML, D’Anto V, Incerti-Parenti S (2015) Cephalometric predictors of treatment outcome with mandibular advancement devices in adult patients with obstructive sleep apnea: a systematic review. Korean J Orthod 45:308–321

    Article  PubMed  PubMed Central  Google Scholar 

  25. Guarda-Nardini L, Manfredini D, Mion M, Heir G, Marchese-Ragona R (2015) Anatomically based outcome predictors of treatment for obstructive sleep apnea with intraoral splint devices: a systematic review of cephalometric studies. J Clin Sleep Med 11:1327–1334

    Article  PubMed  PubMed Central  Google Scholar 

  26. Denolf PL, Vanderveken OM, Marklund ME, Braem MJ (2016) The status of cephalometry in the prediction of non-CPAP treatment outcome in obstructive sleep apnea patients. Sleep Med Rev 27:56–73

    Article  PubMed  Google Scholar 

  27. Doff MH, Hoekema A, Pruim GJ, van der Hoeven JH, de Bont LG, Stegenga B (2009) Effects of a mandibular advancement device on the upper airway morphology: a cephalometric analysis. J Oral Rehabil 36(5):330–337

    Article  PubMed  CAS  Google Scholar 

  28. Eveloff SE, Rosenberg CL, Carlisle CC, Millman RP (1994) Efficacy of a Herbst mandibular advancement device in obstructive sleep apnea. Am J Respir Crit Care Med 149:905–909

    Article  PubMed  CAS  Google Scholar 

  29. Ng AT, Darendeliler MA, Petocz P, Cistulli PA (2012) Cephalometry and prediction of oral appliance treatment outcome. Sleep Breath 16:47–58

    Article  PubMed  Google Scholar 

  30. Mayer G, Meier-Ewert K (1995) Cephalometric predictors for orthopaedic mandibular advancement in obstructive sleep apnoea. Eur J Orthod 17:35–43

    Article  PubMed  CAS  Google Scholar 

  31. Jiang YY (2016) Correlation between hyoid bone position and airway dimensions in Chinese adolescents by cone beam computed tomography analysis. Int J Oral Maxillofac Surg 45:914–921

    Article  PubMed  Google Scholar 

  32. Madsen DP, Sampson WJ, Townsend GC (2008) Craniofacial reference plane variation and natural head position. Eur J Orthod 30:532–540

    Article  PubMed  Google Scholar 

  33. Larson BE (2014) Cone-beam computed tomography is the imaging technique of choice for comprehensive orthodontic assessment. Northwest Dent 93:17–20

    PubMed  Google Scholar 

  34. Battagel JM, Johal A, L’Estrange PR, Croft CB, Kotecha B (1999) Changes in airway and hyoid position in response to mandibular protrusion in subjects with obstructive sleep apnoea (OSA). Eur J Orthod 21:363–376

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Jeong-Whun Kim.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Kim, H.J., Hong, SN., Lee, W.H. et al. Soft palate cephalometric changes with a mandibular advancement device may be associated with polysomnographic improvement in obstructive sleep apnea. Eur Arch Otorhinolaryngol 275, 1811–1817 (2018). https://doi.org/10.1007/s00405-018-5007-3

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  • DOI: https://doi.org/10.1007/s00405-018-5007-3

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