European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 6, pp 1607–1611 | Cite as

Poor oral intake causes enteral nutrition dependency after concomitant chemoradiotherapy for pharyngeal cancers

  • Ryo Ishii
  • Kengo Kato
  • Takenori Ogawa
  • Takeshi Sato
  • Ayako Nakanome
  • Akira Ohkoshi
  • Ai Kawamoto-Hirano
  • Masayuki Shirakura
  • Hiroshi Hidaka
  • Yukio Katori
Head and Neck



To identify precipitating factors responsible for enteral nutrition (EN) dependency after concomitant chemoradiotherapy (CCRT) of head and neck cancers and to examine their statistical correlations.


Factors related to feeding condition, nutritional status, disease, and treatment of 26 oropharyngeal and hypopharyngeal cancer patients who received definitive CCRT were retrospectively investigated by examining their medical records. The days of no oral intake (NOI) during hospitalization and the months using enteral nutrition after CCRT were counted as representing the feeding condition, and the changes in body weight (BW) were examined as reflecting nutritional status. The factors related to EN dependency after CCRT were analyzed.


Long duration of total NOI (≥ 30 days) and maximum NOI ≥ 14 days were significant predictors of EN dependency. Decreased BW (≥ 7.5 kg) was the next predictor identified, but it was not significant. Multivariate analysis showed that the total duration of NOI was more correlated with EN dependency than changes in BW.


A long duration of NOI was more strongly related to EN dependency than nutritional factors.


Head and neck cancer Chemoradiotherapy Nutrition No oral intake Dependency 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otolaryngology-Head and Neck SurgeryTohoku Graduate School of MedicineSendaiJapan

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