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Prognostic value of CD45 transcriptional expression in head and neck cancer

European Archives of Oto-Rhino-Laryngology volume 275, pages 225–232 (2018)Cite this article

Abstract

Introduction

Tumor-infiltrating lymphocytes (TILs) have a recognized antitumor activity in head and neck squamous cell carcinoma (HNSCC). CD45 is one of the most highly expressed proteins in lymphocytes. We carry out a study to assess the prognostic value of transcriptional expression of CD45 in HNSCC.

Material and methods

We determined the transcriptional expression of CD45 in 160 consecutive HNSCC patients and compared the TIL values according to the CD45 expression.

Results

Five-year disease-free survival for patients with a high transcriptional expression of CD45 (n = 107) was 62.4% and for patients with a low expression (n = 53) it was 36.2% (P = 0.003). Patients with a high expression of CD45 had a better local recurrence-free survival and disease-specific survival. The results of a multivariate analysis showed that patients with a low expression of CD45 had 2.0-fold high risk of recurrence (95% CI 1.2–3.2, P = 0.003). In oropharyngeal carcinomas, HPV-positive tumors showed a higher transcriptional CD45 expression than HPV-negative tumors. Tumors with high CD45 expression had immunohistochemical TIL scores significantly higher than those with low CD45 expression.

Conclusion

According to our results, CD45 expression is a potential marker for tumor outcome in HNSCC patients.

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Author information

Affiliations

  1. Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain

    Mercedes Camacho

  2. Otorhinolaryngology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, C/Mas Casanovas, 90, 08041, Barcelona, Spain

    Adriana Agüero, Anna Sumarroca, Jacinto García, Miquel Quer & Xavier León

  3. Pathology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

    Laura López

  4. Infections and Cancer Laboratory, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), L’Hospitalet de Llobregat, Barcelona, Spain

    Miguel-Ángel Pavón

  5. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain

    Miguel-Ángel Pavón & Xavier León

  6. Otorhinolaryngology Department, Hospital Clínic, Barcelona, Spain

    Francesc-Xavier Avilés-Jurado

Authors
  1. Mercedes Camacho
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  2. Adriana Agüero
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  3. Anna Sumarroca
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  4. Laura López
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  5. Miguel-Ángel Pavón
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  6. Francesc-Xavier Avilés-Jurado
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  7. Jacinto García
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  8. Miquel Quer
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  9. Xavier León
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Corresponding author

Correspondence to Xavier León.

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Funding

This work was supported by the Plan Estatal de I + D + I of the Instituto de Salud Carlos III (FIS PI14/01819 to XL, FIS PI15/02047 to FXAJ). Fondo Europeo de Desarrollo Regional (FEDER), A Way to Build Europe.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Due to the retrospective type of the study no formal consent was required.

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Camacho, M., Agüero, A., Sumarroca, A. et al. Prognostic value of CD45 transcriptional expression in head and neck cancer. Eur Arch Otorhinolaryngol 275, 225–232 (2018). https://doi.org/10.1007/s00405-017-4806-2

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  • DOI: https://doi.org/10.1007/s00405-017-4806-2

Keywords

  • CD45
  • Tumor-infiltrating lymphocytes
  • Immune infiltrate
  • Transcriptional expression
  • Head and neck squamous cell carcinoma