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European Archives of Oto-Rhino-Laryngology

, Volume 274, Issue 9, pp 3503–3512 | Cite as

The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule

  • Domenic VitalEmail author
  • Gerhard F. Huber
  • David Holzmann
  • Holger Moch
  • Kristian Ikenberg
Head and Neck

Abstract

The aim of this study was to analyze the role of Ki-67, p53, and the “aberrant p53 pattern” in squamous cell carcinomas of the nasal vestibule. Patients between 1995 and 2014 were included. Baseline characteristics and outcome were analyzed with respect to immunohistochemical staining of Ki-67 and p53. “Aberrant p53 pattern” was represented by a moderate or strong staining of at least 60% of the tumor cells or a complete absence of immunoreactivity. Forty-six patients were included of whom 31 (67.4%) were available for Ki-67 and 32 (69.9%) for p53 immunohistochemistry. The “aberrant pattern” of p53 was present in 50% of the patients. While immunoreactivity for both Ki-67 and p53 was not related to each other or outcome, the “aberrant p53 pattern” was associated with a worse disease-free survival (p = 0.014). The “aberrant p53 pattern” is a negative prognostic factor in squamous cell carcinoma of the nasal vestibule and might enable a patient-tailored treatment.

Keywords

Squamous cell carcinoma Nasal vestibule p53 Aberrant pattern Ki-67 Predictor 

Notes

Compliance with ethical standards

Funding

This work was supported by the KFSP Tumor Oxygenation of the University of Zurich.

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the local authority’s research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

According to the Swiss national law, informed consent is required for this type of retrospective study for all individuals included after January 1, 2014 and was obtained in these cases. For all others, formal consent is not required unless there is a general refusal to be included in retrospective studies.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Domenic Vital
    • 1
    Email author
  • Gerhard F. Huber
    • 1
  • David Holzmann
    • 1
  • Holger Moch
    • 2
  • Kristian Ikenberg
    • 2
  1. 1.Department of Otorhinolaryngology, Head and Neck SurgeryZurich University Hospital and University of ZurichZurichSwitzerland
  2. 2.Department of Pathology and Molecular PathologyZurich University Hospital and University of ZurichZurichSwitzerland

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