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Survival analysis of 287 oropharyngeal squamous cell carcinoma patients in a single institution: a retrospective comparison of two consecutive time intervals with surgical and conservative treatment approaches

  • Head and Neck
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Abstract

This study is a retrospective analysis of clinico-pathological data to investigate survival rates of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with different modalities in a single academic head and neck cancer center in different time intervals. Altogether, 287 patients with OPSCC were included in this comparison. Patients were analysed during two different treatment periods: Group 1 included patients treated mainly with primary surgery ± adjuvant radio(chemo)therapy between 2002 and 2007, while Group 2 included patients treated with organ/function-preservation protocols if indicated. Main outcome measures were overall survival (OS) and recurrence-free survival (RFS). Between 2002 and 2007, early-stage OPSCC showed a 5-year OS of 75% compared to that of 86% between 2008 and 2013. Locally advanced OPSCC showed a 5-year OS of 66% between 2002 and 2007 compared to that of 74% between 2008 and 2013. RFS in early-stage OPSCC was 48% between 2002 and 2007 in contrast to that of 77% between 2008 and 2013. With locally advanced OPSCC, RFS was 55% between 2002 and 2007 compared to that of 56% between 2008 and 2013. These differences were statistically not significant. The OS and RFS remained generally unchanged over the analysed time period. There was no significant difference in the outcomes with regards to HPV status and to their treatment modality.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery and Oncology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Adrian Münscher, Lara Bussmann, Simon Knaack, Alexandra Gliese & Balazs B. Lörincz

  2. Department of Medical Biometry and Epidemiology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Susanne Sehner

  3. Hermann-Holthusen Institute for Radiotherapy of the Asklepios St. Georg Hospital affiliated to the Semmelweis University Budapest, Lohmühlenstr. 5, 20099, Hamburg, Germany

    Silke Tribius

  4. Department of Pathology of the University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Till Clauditz

  5. Department of Otorhinolaryngology, Head and Neck Surgery, Asklepios Altona Hospital affiliated to the Semmelweis University Budapest, Paul-Ehrlich Str. 1, 22763, Hamburg, Germany

    Balazs B. Lörincz

Authors
  1. Adrian Münscher
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  2. Lara Bussmann
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  3. Susanne Sehner
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  4. Simon Knaack
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  5. Alexandra Gliese
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  6. Silke Tribius
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  7. Till Clauditz
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  8. Balazs B. Lörincz
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Corresponding author

Correspondence to Balazs B. Lörincz.

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Funding

This study has not received funding.

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There is no conflict of interest to declare.

Research involving human participants and/or animals

No animals were involved. Human clinico-pathological data were collected retrospectively.

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Not applicable: this was a retrospective study and data were collected in an anonymous fashion.

Additional information

Adrian Münscher and Lara Bussmann share first authorship.

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Münscher, A., Bussmann, L., Sehner, S. et al. Survival analysis of 287 oropharyngeal squamous cell carcinoma patients in a single institution: a retrospective comparison of two consecutive time intervals with surgical and conservative treatment approaches. Eur Arch Otorhinolaryngol 274, 3211–3219 (2017). https://doi.org/10.1007/s00405-017-4615-7

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  • DOI: https://doi.org/10.1007/s00405-017-4615-7

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