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Effect of a liposomal hyaluronic acid gel loaded with dexamethasone in a guinea pig model after manual or motorized cochlear implantation

  • Otology
  • Published:
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Abstract

Goals of cochlear implantation have shifted from complete insertion of the cochlear electrode array towards low traumatic insertion with minimally invasive techniques. The aim of this study was first to evaluate, in a guinea pig model of cochlear implantation, the effect of a motorized insertion technique on hearing preservation. The second goal was to study a new gel formulation containing dexamethasone phosphate loaded in liposomes (DEX-P). Guinea pigs had a unilateral cochlear implantation with either a manual technique (n = 12), or a motorized technique (n = 15), with a 0.4 mm diameter and 4 mm long array trough a cochleostomy. At the end of the procedure, hyaluronic acid gel containing drug-free liposomes, or liposomes loaded with DEX-P, was injected into the bulla. Auditory brainstem responses thresholds were recorded before surgery and day 2 and 7 after surgery. All the animals had increased auditory brainstem responses thresholds after the cochlear implantation. Implanted animals with the motorized insertion tool experienced a partial hearing recovery at day 7 but not in those implanted with the manual insertion procedure (p < 0.001). In the manually implanted animals, a partial recovery was observed when DEX-P contained in liposomal gel was locally administrated (p < 0.0001). Finally, no additive effect with the motorized insertion was noticed. The deleterious effect of manual insertion, during cochlear implantation, can be prevented with local DEX-P administration in the bulla at day 7. The use of a motorized tool performed more atraumatic electrode array insertion for postoperative hearing.

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Authors and Affiliations

  1. UMPC, Paris Sorbonne, INSERM, “Minimally Invasive Robot-based Hearing Rehabilitation”, Paris 6, France

    Elisabeth Mamelle, Olivier Sterkers, Evelyne Ferrary & Yann Nguyen

  2. AP-HP, Pitié-Salpêtrière Hospital, Unit of Otology, Auditory Implants and Skull Base Surgery, Otolaryngology Department, 75013, Paris 6, France

    Elisabeth Mamelle, Benjamin Granger, Olivier Sterkers, Evelyne Ferrary & Yann Nguyen

  3. Institut Galien Paris Sud, CNRS 8612, Paris-Sud, Paris-Saclay University, 92290, Châtenay-Malabry, France

    Naila El Kechai, Amélie Bochot & Florence Agnely

  4. Department of Public Health, AP-HP, Pitié-Salpêtrière Hospital, 75013, Paris, France

    Benjamin Granger

Authors
  1. Elisabeth Mamelle
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  2. Naila El Kechai
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  3. Benjamin Granger
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  4. Olivier Sterkers
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  5. Amélie Bochot
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  6. Florence Agnely
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  7. Evelyne Ferrary
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  8. Yann Nguyen
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Corresponding author

Correspondence to Elisabeth Mamelle.

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Funding

This research was supported by Oticon Medical (Vallauris, France), Agence Nationale de la Recherche, Groupe d’Etude des Maladies de l’Oreille, Fondation pour la Recherche Médicale, INSERM and UPMC. Naila El Kechai acknowledges the Ministère de l’Education Nationale, de l’Enseignement Supérieur et de la Recherche for her PhD grant.

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The authors declare that they have no conflict of interest.

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Mamelle, E., Kechai, N.E., Granger, B. et al. Effect of a liposomal hyaluronic acid gel loaded with dexamethasone in a guinea pig model after manual or motorized cochlear implantation. Eur Arch Otorhinolaryngol 274, 729–736 (2017). https://doi.org/10.1007/s00405-016-4331-8

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  • DOI: https://doi.org/10.1007/s00405-016-4331-8

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