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A comprehensive study of oxidative stress in sudden hearing loss

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Abstract

Little is known about the association between idiopathic sudden sensorineural hearing loss (ISSNHL) and oxidative stress. We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidative imbalance. In the peripheral blood of 50 ISSNHL patients and 50 healthy subjects, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), thiol/disulphide levels were measured. Moreover, a global oxidative stress index, reflecting both oxidative and antioxidant counterparts, was also calculated. One-way analysis between oxidative markers and severity of hearing loss were evaluated. The ISSNHL patients showed significantly higher TOS levels than controls (6.02 ± 3.17 vs. 4.5 ± 2.22; p = 0.018). The oxidative index was also significantly higher in patients than controls (0.39 ± 0.19 vs. 0.3 ± 0.14; p = 0.035). TAS, PON, native thiol, and total thiol were not altered. There was no statistical significance between oxidative markers and severity of hearing loss. The binary logistic regression model revealed that disulphide and TOS were associated with ISSNHL. There are alterations in a wide array of oxidants and antioxidants, with balance shifting toward increased oxidative stress in ISSNHL. Our findings may suggest endothelial dysfunction in ISSNHL etiopathogenesis.

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Acknowledgments

This article is the result of a resident thesis and we would like to thank all the members of the research committee of Ankara Atatürk Training and Research Hospital. We are grateful to all the subjects and parents who participated in the study.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Bitlis Tatvan State Hospital, Tatvan, Bitlis, Turkey

    Fatih Gul

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Training and Research Hospital, Ankara, Turkey

    Togay Muderris & Gokhan Yalciner

  3. Department of Otorhinolaryngology, Head and Neck Surgery, Karaman State Hospital, Karaman, Turkey

    Ergun Sevil

  4. Department of Otorhinolaryngology, Head and Neck Surgery, Yildirim Beyazit University School of Medicine, Ankara, Turkey

    Sami Bercin, Mehmet Ali Babademez & Muzaffer Kiris

  5. Department of Clinical Biochemistry, Gaziantep 25 Aralık State Hospital, Gaziantep, Turkey

    Merve Ergin

Authors
  1. Fatih Gul
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  2. Togay Muderris
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  3. Gokhan Yalciner
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  7. Mehmet Ali Babademez
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  8. Muzaffer Kiris
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Correspondence to Fatih Gul.

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All authors declare that they have no conflict of interest.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Gul, F., Muderris, T., Yalciner, G. et al. A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol 274, 1301–1308 (2017). https://doi.org/10.1007/s00405-016-4301-1

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  • DOI: https://doi.org/10.1007/s00405-016-4301-1

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