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European Archives of Oto-Rhino-Laryngology

, Volume 274, Issue 3, pp 1301–1308 | Cite as

A comprehensive study of oxidative stress in sudden hearing loss

  • Fatih Gul
  • Togay Muderris
  • Gokhan Yalciner
  • Ergun Sevil
  • Sami Bercin
  • Merve Ergin
  • Mehmet Ali Babademez
  • Muzaffer Kiris
Review Article

Abstract

Little is known about the association between idiopathic sudden sensorineural hearing loss (ISSNHL) and oxidative stress. We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidative imbalance. In the peripheral blood of 50 ISSNHL patients and 50 healthy subjects, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), thiol/disulphide levels were measured. Moreover, a global oxidative stress index, reflecting both oxidative and antioxidant counterparts, was also calculated. One-way analysis between oxidative markers and severity of hearing loss were evaluated. The ISSNHL patients showed significantly higher TOS levels than controls (6.02 ± 3.17 vs. 4.5 ± 2.22; p = 0.018). The oxidative index was also significantly higher in patients than controls (0.39 ± 0.19 vs. 0.3 ± 0.14; p = 0.035). TAS, PON, native thiol, and total thiol were not altered. There was no statistical significance between oxidative markers and severity of hearing loss. The binary logistic regression model revealed that disulphide and TOS were associated with ISSNHL. There are alterations in a wide array of oxidants and antioxidants, with balance shifting toward increased oxidative stress in ISSNHL. Our findings may suggest endothelial dysfunction in ISSNHL etiopathogenesis.

Keywords

Sudden sensorineural hearing loss Oxidative stress Total oxidant status Total antioxidant status Paraoxonase Thiol/disulphide homeostasis 

Notes

Acknowledgments

This article is the result of a resident thesis and we would like to thank all the members of the research committee of Ankara Atatürk Training and Research Hospital. We are grateful to all the subjects and parents who participated in the study.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Head and Neck SurgeryBitlis Tatvan State HospitalTatvanTurkey
  2. 2.Department of Otorhinolaryngology, Head and Neck SurgeryAtaturk Training and Research HospitalAnkaraTurkey
  3. 3.Department of Otorhinolaryngology, Head and Neck SurgeryKaraman State HospitalKaramanTurkey
  4. 4.Department of Otorhinolaryngology, Head and Neck SurgeryYildirim Beyazit University School of MedicineAnkaraTurkey
  5. 5.Department of Clinical BiochemistryGaziantep 25 Aralık State HospitalGaziantepTurkey

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