Abstract
The cytochrome P450 2E1 (CYP2E1) polymorphisms have been implicated in susceptibility to nasopharyngeal carcinoma (NPC). However, the results are inconsistent. The aim of this meta-analysis is to evaluate the association between the CYP2E1 polymorphisms and NPC risk. All eligible case–control studies published up to April 4, 2016 were identified by searching PubMed, Web of Science, CNKI, Wanfang and Weipu databases. The NPC risk associated with the CYP2E1 polymorphism was estimated for each study by odds ratios (OR) together with its 95 % confidence interval (CI), respectively. Seven case–control studies were included. Of those, there were seven studies (1302 cases and 1319 controls) for RsaI/PstI polymorphism and three studies (732 cases and 642 controls) for DraI polymorphism. Overall, a significant association was found for RsaI/PstI polymorphism under recessive and homozygote comparison models (OR = 2.72, 95 % CI 1.73–4.25; OR = 2.64, 95 % CI 1.68–4.16, respectively), while there was no significant association for RsaI/PstI polymorphism under other two genetic models. When stratified by ethnicity, similar results were observed between them. As for DraI polymorphism, we also observed a significant association under recessive and homozygote comparison models, but not for the other two models. This meta-analysis suggests that the CYP2E1 polymorphisms contributed to the susceptibility of NPC, especially in Asian populations.
Similar content being viewed by others
References
Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87–108
Chang ET, Adami HO (2006) The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 15:1765–1777
Klein G (2002) Nasopharyngeal carcinoma (NPC) is an enigmatic tumor. Semin Cancer Biol 12:415–418
Bellec G, Dreano Y, Lozach P et al (1996) Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis 17:2029–2034
Gervasi PG, Longo V, Naldi F et al (1991) Xenobiotic-metabolizing enzymes in human respiratory nasal mucosa. Biochem Pharmacol 41:177–184
Hayashi S, Watanabe J, Kawajiri K (1991) Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem 110:559–565
Lu D, Yu X, Du Y (2011) Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer. Mol Biol Rep 38:2409–2416
Uematsu F, Ikawa S, Kikuchi S et al (1994) Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure. Pharmacogenetics 4:58–63
Ben Chaaben A, Abaza H, Douik H et al (2015) Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma. Bull Cancer 102:967–972
Guo X, Zeng Y, Deng H et al (2010) Genetic polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the risk of nasopharyngeal carcinoma in a Han Chinese population of southern China. BMC Res Notes 3:212
He ZM, Yuan JH, Wang SL et al (1999) Association between genetic polymorphism of human cytochrome P450 2E1 gene and susceptibility to nasopharyngeal carcinoma. Ai Zheng (Chinese) 18:517–519
Hildesheim A, Anderson LM, Chen CJ et al (1997) CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 89:1207–1212
Hildesheim A, Chen CJ, Caporaso NE et al (1995) Cytochrome P4502E1 genetic polymorphisms and risk of nasopharyngeal carcinoma: results from a case–control study conducted in Taiwan. Cancer Epidemiol Biomarkers Prev 4:607–610
Kongruttanachok N, Sukdikul S, Setavarin S et al (2001) Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study. BMC Cancer 1:4
Lourembam DS, Singh AR, Sharma TD et al (2015) Evaluation of risk factors for nasopharyngeal carcinoma in a high-risk area of India, the northeastern region. Asian Pac J Cancer Prev 16:4927–4935
Dodd LE, Sengupta S, Chen IH et al (2006) Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 15:2216–2225
Jia WH, Pan QH, Qin HD et al (2009) A case–control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk in Cantonese. Carcinogenesis 30:2031–2036
Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127:820–826
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634
Zheng YM, Tuppin P, Hubert A et al (1994) Environmental and dietary risk factors for nasopharyngeal carcinoma: a case–control study in Zangwu County, Guangxi, China. Br J Cancer 69:508–514
Lucas D, Menez C, Girre C et al (1995) Cytochrome P4502E1 genotype and chloroxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics 5:298–304
Kim RB, Yamazaki H, Chiba K et al (1996) In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. J Pharmacol Exp Ther 279:4–11
Yang J, Li L, Yin X et al (2015) The association between gene polymorphisms and risk of nasopharyngeal carcinoma. Med Oncol 32:398
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
We declare that we have no conflict of interest.
Ethical approval
This article does not contain any studies with human participants performed by any of the authors.
Rights and permissions
About this article
Cite this article
Yao, K., Qin, H., Gong, L. et al. CYP2E1 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis. Eur Arch Otorhinolaryngol 274, 253–259 (2017). https://doi.org/10.1007/s00405-016-4236-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-016-4236-6