Will the mininvasive approach challenge the old paradigms in oral cancer surgery?

European Archives of Oto-Rhino-Laryngology volume 274, pages1279–1289(2017)Cite this article

Abstract

In the genome era, the achievement of a safe and complete resection of oral cancers remains a challenge for surgeons. Margin length at histopathological examination is still considered the main indicator of oncological radicality. However, this parameter is fraught by major limitations. Cancer aggressiveness, and in particular its ability to spread in the surrounding tissue, most probably influences loco-regional control and prognosis more than margin length. Unfortunately, no molecular markers are currently available to predict tumor aggressiveness pre-operatively. However, additional histopathological parameters, beside margin length, could be considered to better stratify oral tumors, including depth of invasion (DOI), perineural invasion or composite scores. Recent advances in laser technology have established a novel surgical trend toward a minimalist approach, named transoral laser microsurgery (TLM). TLM provides a local control rate comparable to the one achieved by larger resections if the margin appears disease free, independent from its length. In addition, the clinical availability of innovative optical technologies, such as narrow band imaging (NBI) or autofluorescence, allows more precise and tailored resections, not simply based on clinical observation and ruler measurement. This review will propose the possible implementation of novel procedures toward a mini-invasive surgical approach, providing a satisfactory control rate but significantly improving the quality of life of the patients compared to conventional surgery.

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Affiliations

  1. Department of Otolaryngology and Head and Neck Surgery, Cattinara Hospital, University of Trieste, Trieste, Italy

    G. Tirelli, F. Boscolo Nata, E. Quatela & M. Piovesana

  2. Molecular Medicine, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

    S. Zacchigna

  3. Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy

    R. Di Lenarda

Authors
  1. G. Tirelli
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  2. S. Zacchigna
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  3. F. Boscolo Nata
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  4. E. Quatela
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  5. R. Di Lenarda
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  6. M. Piovesana
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Correspondence to M. Piovesana.

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Tirelli, G., Zacchigna, S., Boscolo Nata, F. et al. Will the mininvasive approach challenge the old paradigms in oral cancer surgery?. Eur Arch Otorhinolaryngol 274, 1279–1289 (2017). https://doi.org/10.1007/s00405-016-4221-0

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Keywords

  • Oral squamous cell carcinoma
  • Surgical margins
  • Shrinkage of specimens
  • Transoral laser microsurgery
  • Optical imaging
  • Quality of life