European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 11, pp 3795–3801 | Cite as

A meta-analysis for the role of proton pump inhibitor therapy in patients with laryngopharyngeal reflux

  • Chunhui Wei


We aimed to systematically review the randomized controlled trials (RCTs) regarding the therapeutic efficiency of proton pump inhibitor (PPI) therapy for laryngopharyngeal reflux (LPR). Randomized and placebo-controlled trials regarding the therapeutic efficacy of PPIs on LPR patients were systematically searched from MEDLINE, Cochrane Library, and EMBASE. Data were extracted from eligible studies meeting the inclusion criteria. Heterogeneity among these eligible studies was evaluated by the Q-statistic and I 2 test, based on which a fixed- or random-effects model was performed to pooled relative risks (RRs) for the response rate and standardized mean differences (SMDs) for reflux symptom index (RSI) and the reflux finding score (RFS). Potential publication bias was evaluated by trim and fill method. Totally, 13 RCTs including 831 LPR patients were eligible for this meta-analysis. Pooled results demonstrated that the total RSI significantly improved for patients who received PPI therapy by comparing with those receiving placebo (SMD = 3.65; 95 % CI 1.56–5.75), though no significant difference was found in response rate (RR = 0.04, 95 % CI −0.06 to 0.14) and RFS (SMD = 0.91; 95 % CI −0.53 to 2.35) between these two groups of patients. No publication bias was found among eligible studies. PPI treatment could significantly improve reflux symptoms in LPR patients and, therefore, should be taken into consideration for LPR management with other strategies, such as lifestyle modification.


Proton pump inhibitor Laryngopharyngeal reflux Meta-analysis 


Compliance with ethical standards



Conflict of interest

All the authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Otolaryngology-Head Neck SurgeryBeijing Friendship Hospital Attached of Capital Medical UniversityBeijingChina

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