European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 9, pp 2735–2740 | Cite as

Evaluation of health-related quality of life with EORTC QLQ-C30 and QLQ-H&N35 in Romanian laryngeal cancer patients

  • F. V. Dinescu
  • C. Ţiple
  • Magdalena Chirilă
  • R. Mureşan
  • T. Drugan
  • M. Cosgarea
Head and Neck


The aims of this study were to evaluate the health-related quality of life (HRQL) according to: type of surgery, adjuvant oncological treatment and postoperative complications. We performed a retrospective case–control study between October 2013 and November 2014 at the Ear Nose and Throat Clinic of Cluj-Napoca. We included patients diagnosed with laryngeal or hypopharyngeal cancer treated with total or partial laryngectomy, and a sample of healthy volunteers recruited from the hospital stuff. We used the European Organisation for Research and Treatment of Cancer (EOTRC) core questionnaires (the QLQ-C30 version 3) and the head and neck cancer module (the QLQ-H&N35). We included in the study 80 patients diagnosed and surgically treated for laryngeal/hypopharyngeal squamous cell carcinoma and 20 healthy volunteers. Median age of the patients was 59.90 years. The most common location was the larynx, in 72 (90 %) of cases and the hypopharynx in 8 (10 %) cases. Sixty-six (82, 50 %) underwent total laryngectomy and 14 (17, 50 %) a partial laryngectomy. Forty-eight patients had received external radiation therapy, with adjuvant chemotherapy in 25 patients. Postoperative complication rates were 14 (17, 50 %) cases. We found a low score in total laryngectomy group regarding functional scales: role (28.03), emotional (37.75) and social (37.88) and a high score on insomnia (35.86) and financial difficulties (45.45). Partial laryngectomy group had a high score on functional scales: role (47.62), emotional (51.19) and social (52.38). These two QOL instruments were effective for Romanian patients. The QLQ-H&N35 questionnaire discriminating better the problems between groups compared with QLQ-C30.


Quality of life Laryngeal cancer EORTC QLQ-C30 EORTC QLQ-H&N35 



This paper was published under the frame of European Social Fund, Human Resources Development Operational Programme 2007-2013, project no. POSDRU/159/1.5/S/138776 and SWARA Project, PN-II-PT-PCCA-2013-4-1660, Contract no. 6/2014.

Compliance with ethical standards

Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • F. V. Dinescu
    • 1
  • C. Ţiple
    • 1
  • Magdalena Chirilă
    • 1
  • R. Mureşan
    • 2
  • T. Drugan
    • 3
  • M. Cosgarea
    • 1
  1. 1.Department of OtorhinolaryngologyIuliu Hatieganu University of Medicine and PharmacyCluj-NapocaRomania
  2. 2.Department of OtorhinolaryngologyEmergency County HospitalCluj-NapocaRomania
  3. 3.Department of Medical Informatics and Biostatistic DepartmentIuliu Hatieganu University of Medicine and PharmacyCluj-NapocaRomania

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