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Two-stage autotransplantation of human submandibular gland: a novel approach to treat postradiogenic xerostomia

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Xerostomia is a persistent side effect of radiotherapy (RT), which severely reduces the quality of life of the patients affected. Besides drug treatment and new irradiation strategies, surgical procedures aim for tissue protection of the submandibular gland. Using a new surgical approach, the submandibular gland was autotransplanted in 6 patients to the patient’s forearm for the period of RT and reimplanted into the floor of the mouth 2–3 months after completion of RT. Saxon’s test was performed during different time points to evaluate patient’s saliva production. Furthermore patients had to answer EORTC QLQ-HN35 questionnaire and visual analog scale. Following this two-stage autotransplantation, xerostomia in the patients was markedly reduced due to improved saliva production of the reimplanted gland. Whether this promising novel approach is a reliable treatment option for RT patients in general should be evaluated in further studies.

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Authors and Affiliations

  1. University Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, Josef-Schneider Str. 11, 97080, Würzburg, Germany

    Rudolf Hagen, Matthias Scheich & Norbert Kleinsasser

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Stuttgart, Stuttgart, Germany

    Marc Burghartz

Authors
  1. Rudolf Hagen
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  2. Matthias Scheich
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  3. Norbert Kleinsasser
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  4. Marc Burghartz
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Correspondence to Rudolf Hagen.

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Hagen, R., Scheich, M., Kleinsasser, N. et al. Two-stage autotransplantation of human submandibular gland: a novel approach to treat postradiogenic xerostomia. Eur Arch Otorhinolaryngol 273, 2217–2222 (2016). https://doi.org/10.1007/s00405-015-3752-0

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  • DOI: https://doi.org/10.1007/s00405-015-3752-0

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