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The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population

  • Otology
  • Published:
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Abstract

This study aimed to test the association between the European GWAS-identified risk IQGAP2 SNP rs457717 (A>G) and age-related hearing impairment (ARHI) in a Han male Chinese (HMC) population. A total of 2420 HMC subjects were divided into two groups [group 70+: >70 years (n = 1306), and group 70−: ≤70 years (n = 1114)]. The participants were categorised into case and control groups according to Z high scores for group 70− and the severity of hearing loss and different audiogram shapes identified by K-means cluster analysis for group 70+. The IQGAP2 tagSNP rs457717 was genotyped in accordance with the different ARHI phenotypes. The genotype distributions of IQGAP2 (AA/AG/GG) were not significantly different between the case and control groups (P = 0.613 for group 70−; P = 0.602 for group 70+). Compared with genotype AA, the ORs of genotypes AG and GG for ARHI were not significantly different following adjustment for other environmental risk factors. We demonstrated that the IQGAP2 TagSNP rs457717 (A/G) was not associated with ARHI in HMC individuals.

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Acknowledgments

This research was supported by grants from Medical Engineering (Technology) Cross Research Fund, Shanghai Jiao Tong University (No. YG2014MS47), and grants from the Medical Research Fund of Shanghai Municipal Health and Family Planning Commission (No. 201440295).

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Authors and Affiliations

  1. Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road Pudong New Area, Shanghai, 200127, People’s Republic of China

    Huajie Luo, Xiaojie Jin & Jiping LI

  2. Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China

    Hao Wu, Tao Yang, Zhiwu Huang, Xiuhong Pang, Lei Li & Xianting Hu

  3. Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China

    Hao Wu, Tao Yang, Zhiwu Huang, Xiuhong Pang, Lei Li & Xuemei Jiang

  4. Renji-Med X Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China

    Hailian Shen

  5. Shanghai Center for Bioinformation Technology, Shanghai, 200235, People’s Republic of China

    Haifeng Chen

  6. Department of Bioinformatics and Biostatistics, College of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, 200240, People’s Republic of China

    Haifeng Chen

  7. Health Check-up Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China

    Zhuping Fan

  8. Health Check-up Center, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China

    Xuemei Jiang

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  1. Huajie Luo
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  2. Hao Wu
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Correspondence to Jiping LI.

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Luo, H., Wu, H., Shen, H. et al. The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population. Eur Arch Otorhinolaryngol 273, 1677–1687 (2016). https://doi.org/10.1007/s00405-015-3711-9

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