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Are small olfactory bulbs a risk for olfactory loss following an upper respiratory tract infection?

European Archives of Oto-Rhino-Laryngology volume 272, pages 3593–3594 (2015)Cite this article

Abstract

Considering the correlation between olfactory function and size of the human olfactory bulb (OB), it may be that OB volume is representative of the average number of functional olfactory receptor neurons in the nose. We observed a woman (64-year-old) with a 3-week history of hyposmia following an upper respiratory tract infection. Interestingly, both OB volumes were below the tenth percentile of the general population which seems to be difficult to explain by rapid, adaptive changes in the OB volume. It is hypothesized that small OBs may be a risk factor for acquiring olfactory loss.

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References

  1. Buschhuter D, Smitka M et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42(2):498–502

    CAS  Article  PubMed  Google Scholar 

  2. Cummings DM, Knab BR et al (1997) Effects of unilateral olfactory deprivation in the developing opossum, Monodelphis domestica. J Neurobiol 33:429–438

    CAS  Article  PubMed  Google Scholar 

  3. Gudziol V, Buschhuter D et al (2009) Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study. Brain 132(Pt 11):3096–3101

    CAS  Article  PubMed  Google Scholar 

  4. Haehner A, Rodewald A et al (2008) Changes of the volume of the human olfactory bulb with olfactory function. Arch ORL 134:621–624

    Google Scholar 

  5. Hummel T, Kobal G et al (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243

    CAS  Article  PubMed  Google Scholar 

  6. Korol DL, Brunjes PC (1992) Unilateral naris closure and vascular development in the rat olfactory bulb. Neuroscience 46:631–641

    CAS  Article  PubMed  Google Scholar 

  7. Leopold DA, Hornung DE et al (1991) Olfactory loss after upper respiratory infection. In: Getchell TV, Doty RL, Bartoshuk LM, Snow JB (eds) Smell and taste in health and disease. Raven Press, New York, pp 731–734

    Google Scholar 

  8. Paskin TR, Iqbal TR et al (2011) Olfactory bulb recovery following reversible deafferentation with repeated detergent application in the adult zebrafish. Neuroscience 196:276–284

    CAS  Article  PubMed  Google Scholar 

  9. Rombaux P, Duprez T et al (2009) Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology 47:3–9

    CAS  PubMed  Google Scholar 

  10. Seiden AM (2004) Postviral olfactory loss. Otolaryngol Clin North Am 37:1159–1166

    Article  PubMed  Google Scholar 

  11. von Gudden B (1870) Experimentaluntersuchungen ueber das periphere und zentrale Nervensystem. Archiv f Psychiatrie u Nervenkrankheiten 2:693–723

    Article  Google Scholar 

  12. Yousem DM, Geckle RJ et al (1999) Posttraumatic smell loss: relationship of psychophysical tests and volumes of the olfactory bulbs and tracts and the temporal lobes. Acad Radiol 6:264–272

    CAS  Article  PubMed  Google Scholar 

Download references

Conflict of interest

All authors declare that they have no financial interest or benefit arising from the direct applications of their research.

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Affiliations

  1. Department of Otorhinolaryngology, Smell and Taste Clinic, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany

    A. Patterson, A. Hähner & Thomas Hummel

  2. Department of Neuroradiology, TU Dresden, Dresden, Germany

    H. H. Kitzler

Authors
  1. A. Patterson
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  2. A. Hähner
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  3. H. H. Kitzler
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  4. Thomas Hummel
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Correspondence to Thomas Hummel.

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Patterson, A., Hähner, A., Kitzler, H.H. et al. Are small olfactory bulbs a risk for olfactory loss following an upper respiratory tract infection?. Eur Arch Otorhinolaryngol 272, 3593–3594 (2015). https://doi.org/10.1007/s00405-015-3524-x

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  • DOI: https://doi.org/10.1007/s00405-015-3524-x

Keywords

  • Smell
  • Flavor
  • MRI
  • Anosmia