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Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. The Korean herbal medicine, So-Cheong-Ryong-Tang (SCRT) has been typically used for the treatment of AR for hundreds of years. In the present study, we investigated whether SCRT suppresses the progression of AR in animal model. AR was induced by ovalbumin (OVA). Treatment with SCRT was assessed to study the effect of SCRT on AR in mice. Histological analysis, multiplex cytokine assay, blood analysis, cell viability assay, RT-PCR and Elisa assay were performed to verify inhibitory effect of SCRT on AR. SCRT reduced infiltration of inflammatory cells into nasal cavity. SCRT reduced infiltration of mast cells into nasal mucosa. SCRT reduced the levels of cytokines (IL-4 and LIF) in the serum. SCRT reduced the levels of leukocytes in the blood. SCRT decreased cell viability of HMC-1 cells and splenocyte. SCRT suppressed IL-4 level in HMC-1 cells and splenocyte cells in a dose-dependent manner. SCRT suppressed IL-6 level and TNF-α level in splenocyte. SCRT suppresses the progression of AR induced by OVA. SCRT might be a useful drug for the treatment of AR.

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References

  1. Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CC, Schuller D, Spector SL, Tilles SA (2008) The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122(2 Suppl):S1–S84. doi:10.1016/j.jaci.2008.06.003

    Article  PubMed  Google Scholar 

  2. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, Agache I, Ait-Khaled N, Bachert C, Blaiss MS, Bonini S, Boulet LP, Bousquet PJ, Camargos P, Carlsen KH, Chen Y, Custovic A, Dahl R, Demoly P, Douagui H, Durham SR, van Wijk RG, Kalayci O, Kaliner MA, Kim YY, Kowalski ML, Kuna P, Le LT, Lemiere C, Li J, Lockey RF, Mavale-Manuel S, Meltzer EO, Mohammad Y, Mullol J, Naclerio R, O’Hehir RE, Ohta K, Ouedraogo S, Palkonen S, Papadopoulos N, Passalacqua G, Pawankar R, Popov TA, Rabe KF, Rosado-Pinto J, Scadding GK, Simons FE, Toskala E, Valovirta E, van Cauwenberge P, Wang DY, Wickman M, Yawn BP, Yorgancioglu A, Yusuf OM, Zar H, Annesi-Maesano I, Bateman ED, Ben Kheder A, Boakye DA, Bouchard J, Burney P, Busse WW, Chan-Yeung M, Chavannes NH, Chuchalin A, Dolen WK, Emuzyte R, Grouse L, Humbert M, Jackson C, Johnston SL, Keith PK, Kemp JP, Klossek JM, Larenas-Linnemann D, Lipworth B, Malo JL, Marshall GD, Naspitz C, Nekam K, Niggemann B, Nizankowska-Mogilnicka E, Okamoto Y, Orru MP, Potter P, Price D, Stoloff SW, Vandenplas O, Viegi G, Williams D (2008) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63(Suppl 86):8–160. doi:10.1111/j.1398-9995.2007.01620.x

    Article  PubMed  Google Scholar 

  3. Smurthwaite L, Walker SN, Wilson DR, Birch DS, Merrett TG, Durham SR, Gould HJ (2001) Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur J Immunol 31(12):3422–3431. doi:10.1002/1521-4141(200112)31:12<3422

    Article  PubMed  CAS  Google Scholar 

  4. Boyce JA (2003) Mast cells: beyond IgE. J Allergy Clin Immunol 111(1):24–32 (quiz 33) doi:S0091674902913229 [pii]

  5. Borish L (2003) Allergic rhinitis: systemic inflammation and implications for management. J Allergy Clin Immunol 112(6):1021–1031. doi:10.1016/j.jaci.2003.09.015

    Article  PubMed  CAS  Google Scholar 

  6. Hamilos DL, Leung DY, Wood R, Cunningham L, Bean DK, Yasruel Z, Schotman E, Hamid Q (1995) Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol 96 (4):537-544. pii S0091674995002661

  7. Braunstahl GJ, Kleinjan A, Overbeek SE, Prins JB, Hoogsteden HC, Fokkens WJ (2000) Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med 161(6):2051–2057. doi:10.1164/ajrccm.161.6.9906121

    Article  PubMed  CAS  Google Scholar 

  8. Cameron L, Hamid Q, Wright E, Nakamura Y, Christodoulopoulos P, Muro S, Frenkiel S, Lavigne F, Durham S, Gould H (2000) Local synthesis of epsilon germline gene transcripts, IL-4, and IL-13 in allergic nasal mucosa after ex vivo allergen exposure. J Allergy Clin Immunol 106(1 Pt 1):46–52. pii:S0091674900635443

  9. Nouri-Aria KT, O’Brien F, Noble W, Jabcobson MR, Rajakulasingam K, Durham SR (2000) Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils. Clin Exp Allergy 30(12):1709–1716. pii:cea998

  10. Bousquet J, Van Cauwenberge P, Khaltaev N (2001) Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108(5 Suppl):S147–334. pii:a118891

  11. Bascom R, Pipkorn U, Lichtenstein LM, Naclerio RM (1988) The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of systemic steroid pretreatment. Am Rev Respir Dis 138(2):406–412. doi:10.1164/ajrccm/138.2.406

    Article  PubMed  CAS  Google Scholar 

  12. Plaut M, Valentine MD (2005) Clinical practice. Allergic rhinitis. N Engl J Med 353(18):1934–1944. doi:10.1056/NEJMcp044141

    Article  PubMed  CAS  Google Scholar 

  13. Nathan RA (2007) The burden of allergic rhinitis. Allergy Asthma Proc 28(1):3–9

    Article  PubMed  Google Scholar 

  14. Yu C, Xiao YZ, Xun PH, Dai L, Han J, Yuan HL (2014) Preparation and characterization of cucurbitacin B sodium deoxycholate/phospholipid-mixed oral fast dissolving film and antitumor activity study. Zhongguo Zhong Yao Za Zhi 39(10):1799–1804

    PubMed  CAS  Google Scholar 

  15. Nagai T, Arai Y, Emori M, Nunome SY, Yabe T, Takeda T, Yamada H (2004) Anti-allergic activity of a Kampo (Japanese herbal) medicine “Sho-seiryu-to (Xiao-Qing-Long-Tang)” on airway inflammation in a mouse model. Int Immunopharmacol 4(10–11):1353–1365. doi:10.1016/j.intimp.2004.05.021

    Article  PubMed  CAS  Google Scholar 

  16. Kao ST, Wang SD, Wang JY, Yu CK, Lei HY (2000) The effect of Chinese herbal medicine, xiao-qing-long tang (XQLT), on allergen-induced bronchial inflammation in mite-sensitized mice. Allergy 55(12):1127–1133

    Article  PubMed  CAS  Google Scholar 

  17. Kao ST, Lin CS, Hsieh CC, Hsieh WT, Lin JG (2001) Effects of xiao-qing-long-tang (XQLT) on bronchoconstriction and airway eosinophil infiltration in ovalbumin-sensitized guinea pigs: in vivo and in vitro studies. Allergy 56(12):1164–1171. pii:982

  18. Sakaguchi M, Mase A, Ikeda Y, Iizuka A, Imamura S, Komatsu Y, Ukai K, Sakakura Y (1999) Effects of Sho-seiryu-to on experimental allergic rhinitis in guinea pigs. Methods Find Exp Clin Pharmacol 21(4):303–308

    Article  PubMed  CAS  Google Scholar 

  19. Meltzer EO (1997) The prevalence and medical and economic impact of allergic rhinitis in the United States. J Allergy Clin Immunol 99(6 Pt 2):S805–S828

  20. Adams PF, Hendershot GE (1996) Marano MA (1999) Current estimates from the National Health Interview Survey. Vital Health Stat 10(200):1–203

    Google Scholar 

  21. Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM (1994) Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics 94(6 Pt 1):895–901

    PubMed  CAS  Google Scholar 

  22. Nagai T, Kiyohara H, Munakata K, Shirahata T, Sunazuka T, Harigaya Y, Yamada H (2002) Pinellic acid from the tuber of Pinellia ternata Breitenbach as an effective oral adjuvant for nasal influenza vaccine. Int Immunopharmacol 2(8):1183–1193

    Article  PubMed  CAS  Google Scholar 

  23. Lee B, Shin YW, Bae EA, Han SJ, Kim JS, Kang SS, Kim DH (2008) Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol. Arch Pharm Res 31(4):445–450. doi:10.1007/s12272-001-1177-6

    Article  PubMed  CAS  Google Scholar 

  24. Kim HM, Moon YS (1999) Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo. Immunopharmacol Immunotoxicol 21(3):469–481. doi:10.3109/08923979909007121

    Article  PubMed  CAS  Google Scholar 

  25. Lee MY, Seo CS, Lee NH, Ha H, Lee JA, Lee H, Lee KY, Shin HK (2010) Anti-asthmatic effect of schizandrin on OVA-induced airway inflammation in a murine asthma model. Int Immunopharmacol 10(11):1374–1379. doi:10.1016/j.intimp.2010.07.014

    Article  PubMed  CAS  Google Scholar 

  26. Ahui ML, Champy P, Ramadan A, Van Pham L, Araujo L, Brou Andre K, Diem S, Damotte D, Kati-Coulibaly S, Offoumou MA, Dy M, Thieblemont N, Herbelin A (2008) Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation. Int Immunopharmacol 8(12):1626–1632. doi:10.1016/j.intimp.2008.07.009

    Article  PubMed  CAS  Google Scholar 

  27. Davidovich-Rikanati R, Shalev L, Baranes N, Meir A, Itkin M, Cohen S, Zimbler K, Portnoy V, Ebizuka Y, Shibuya M, Burger Y, Katzir N, Schaffer AA, Lewinsohn E, Tadmor Y (2014) Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp.). Yeast. doi:10.1002/yea.3049

  28. Li XL, Zhou AG (2012) Evaluation of the immunity activity of glycyrrhizin in AR mice. Molecules 17(1):716–727. doi:10.3390/molecules17010716

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by the Kyung Hee University in 2012. This work was supported by a grant funded by the Traditional Korean Medicine R&D Project of the Ministry for Health & Welfare (No. HI12C1889).

Conflict of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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Authors and Affiliations

  1. Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Jin Mo Ku, Se Hyang Hong, Soon Re Kim, Han-Seok Choi, Hye Sook Seo, Bo-Hyoung Jang, Seong-Gyu Ko & Yong Cheol Shin

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  1. Jin Mo Ku
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Correspondence to Yong Cheol Shin.

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Ku, J.M., Hong, S.H., Kim, S.R. et al. Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model. Eur Arch Otorhinolaryngol 273, 123–131 (2016). https://doi.org/10.1007/s00405-015-3515-y

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