Abstract
Sinonasal Rosai-Dorfman disease (S-RDD) is a rare form of RDD limited to the sinonasal cavity. Multipatient studies of Chinese S-RDD and documentation of its clinical spectrum are rare. This study aimed to identify the clinical profiles of Chinese S-RDD. Medical records of and tissue sections from 10 patients diagnosed with S-RDD between 2007 and 2014 were reviewed. Data on clinical presentations, endoscopy signs, imageological change, treatment and outcome were analyzed. The mean age of five male and five female patients at the first visit was 40.3 years and the mean follow-up period was 58.6 months. Based on the lesion sites, five cases were divided into an anterior sinonasal group, accompanied by symptoms of epistaxis, nasal obstruction and nasal dorsal deformity. Five other cases were divided into a posterior sinonasal group, accompanied by symptoms of hyposmia, epistaxis and nasal obstruction. Endoscopy signs and imageological changes in the anterior group showed diffuse infiltration of the RDD lesion under the septum mucosa, but in the posterior group the RDD lesions often showed as formations on polyps. At the end of follow-up, only one case spontaneously resolved without surgery; two cases in the anterior sinonasal group and three cases in the posterior sinonasal group recurred after endoscopic surgery, but surgery can result in short-term symptomatic control and restoration of function in all cases. S-RDD of the anterior and posterior sinonasal cavity may have different clinical characteristics; endoscopic surgery is effective for short-term symptomatic control and restoration of function for S-RDD.
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References
Rosai J, Dorfman RF (1969) Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 87:63–70
Foucar E, Rosai J, Dorfman R (1990) Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 7:19–73
Lauwers GY, Perez-Atayde A, Dorfman RF, Rosai J (2000) The digestive system manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases. Hum Pathol 31:380–385
Wang KH, Chen WY, Liu HN, Huang CC, Lee WR, Hu CH (2006) Cutaneous Rosai-Dorfman disease: clinicopathological profiles, spectrum and evolution of 21 lesions in six patients. Br J Dermatol 154:277–286
Chen HH, Zhou SH, Wang SQ, Teng XD, Fan J (2012) Factors associated with recurrence and therapeutic strategies for sinonasal Rosai-Dorfman disease. Head Neck 34:1504–1513
Chang YC, Tsai MH, Chen CL, Tsai CH, Lee AY (2003) Nasal Rosai-Dorfman disease with intracranial involvement: a case report. Am J Otolaryngol 24:183–186
Hsiao CH, Tsai TF, Yang TH, Liu CM (2006) Clinicopathologic characteristics of Rosai-Dorfman disease in a medical center in northern Taiwan. J Formos Med Assoc 105:701–707
Aozasa K, Zaki MA (2011) Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review. Sci World J 11:422–428
Pulsoni A, Anghel G, Falcucci P, Matera R, Pescarmona E, Ribersani M (2002) Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol 69:67–71
Hadjipanayis CG, Bejjani G, Wiley C, Hasegawa T, Maddock M, Kondziolka D (2003) Intracranial Rosai-Dorfman disease treated with microsurgical resection and stereotactic radiosurgery Case report. J Neurosurg 98:165–168
Oka M, Kamo T, Goto N, Nagano T, Hirayama Y, Nibu K (2009) Successful treatment of Rosai-Dorfman disease with low-dose oral corticosteroid. J Dermatol 36:237–240
Horneff G, Jurgens H, Hort W, Karitzky D, Gobel U (1996) Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): response to methotrexate and mercaptopurine. Med Pediatr Oncol 27:187–192
Cooper SL, Chavis PS, Fortney JA, Watkins JM, Caplan MJ, Jenrette JR (2008) A case of orbital Rosai-Dorfman disease responding to radiotherapy. J Pediatr Hematol Oncol 30:744–748
Ku PK, Tong MC, Leung CY, Pak MW, van Hasselt CA (1999) Nasal manifestation of extranodal Rosai-Dorfman disease—diagnosis and management. J Laryngol Otol 113:275–280
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Duan, HG., Zheng, CQ., Wang, DH. et al. Extranodal sinonasal Rosai-Dorfman disease: a clinical study of 10 cases. Eur Arch Otorhinolaryngol 272, 2313–2318 (2015). https://doi.org/10.1007/s00405-014-3297-7
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DOI: https://doi.org/10.1007/s00405-014-3297-7