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The role of elastography in evaluating thyroid nodules: a literature review and meta-analysis

European Archives of Oto-Rhino-Laryngology volume 272, pages 1845–1855 (2015)Cite this article

Abstract

To appraise the literature for studies involving the use of elastography to diagnose thyroid nodule pathology. Two independent reviewers performed a systematic review of the English medical literature for studies involving elastography diagnosing thyroid nodule pathology. Data gleaned from this process was used in a meta-analysis to summarise the results. Thirty-eight studies were used in the meta-analysis totalling 5,942 thyroid nodules examined with elastography. The pooled results were sensitivity = 87.0 % (95 % confidence intervals (CI) = 86.2–87.9 %), specificity = 80.6 % (CI = 79.5–81.6 %), positive predictive value (PPV) = 48.9 % (CI = 47.6–50.2 %), negative predictive value (NPV) = 96.7 % (CI = 96.2–97.1 %), diagnostic accuracy = 81.7 % (CI = 80.7–82.7 %). Subgroup analysis of the data is also presented. Elastography has its limitations in the diagnosis of thyroid nodules; however, its high NPV is increasingly being used as an important investigation and may allow a reduction in the number of hemi-thyroidectomies with benign pathology. Subgroup analysis suggests that elastography techniques where compressive force is performed in a non-user-dependant method results in improved final results.

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Acknowledgments

Dr Andrew McQueen, Consultant Head & Neck Radiologist, Freeman hospital, Newcastle, England for his invaluable advice and for providing the images of elastography scans. Ali Nikkar, ENT StR, Nottingham general hospital, England for procuring some of the publications for the meta-analysis.

Conflict of interest

There was no sponsorship or funding for this project, and no conflict of interest to declare.

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Affiliations

  1. James Cook University Hospital, Marton Rd, Middlesbrough, TS4 3BW, England, UK

    Vik Veer

  2. Glasgow Royal Infirmary, 84 Castle St, Glasgow, Glasgow City, G4 0SF, Scotland, UK

    Srikanth Puttagunta

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  1. Vik Veer
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Correspondence to Vik Veer.

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Veer, V., Puttagunta, S. The role of elastography in evaluating thyroid nodules: a literature review and meta-analysis. Eur Arch Otorhinolaryngol 272, 1845–1855 (2015). https://doi.org/10.1007/s00405-014-3155-7

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  • DOI: https://doi.org/10.1007/s00405-014-3155-7

Keywords

  • Thyroid nodules
  • Ultrasound
  • Elastography