Skip to main content

Advertisement

SpringerLink
Log in

Sex-specific association of RANTES gene −403 variant in Meniere’s disease

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Several studies have shown the correlation between RANTES gene and inflammatory disorders; the aim of the present study was to investigate the association between RANTES promoter gene polymorphism and Meniere’s disease (MD) in an Iranian population. In this study patients with MD comprising definite MD (N = 56) and probable MD (N = 15) were selected according to diagnostic criteria of AAO-HNS. The control group (N = 101) were healthy normal subjects who did not have a history of ear disease and vertigo. PCR–RFLP for RANTES −403G>A has been performed. We found a protective role for RANTES −403A allele in male group in our population. None of the male patients with MD were carrier of allele A which was significantly different from the presence of allele A in the male control group (AA+GA vs. GG: p = 0.0004, OR 0.05, 95 % CI 0.001–0.39). This difference was not significant in female group. There was no significant association between RANTES gene polymorphism and the level of hearing loss. our results showed a sex-specific association between RANTES gene polymorphism and MD but more studies are necessary to further assess this association.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. An P et al (2002) Modulating influence on HIV/AIDS by interacting RANTES gene variants. Proc Natl Acad Sci USA 99(15):10002–10007

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. McDermott DH et al (2000) Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study. AIDS 14(17):2671–2678

    Article  CAS  PubMed  Google Scholar 

  3. Nickel RG et al (2000) Atopic dermatitis is associated with a functional mutation in the promoter of the c-c chemokine RANTES. J Immunol 164(3):1612–1616

    Article  CAS  PubMed  Google Scholar 

  4. Maghazachi AA, Al-Aoukaty A, Schall TJ (1996) CC chemokines induce the generation of killer cells from CD56+ cells. Eur J Immunol 26(2):315–319

    Article  CAS  PubMed  Google Scholar 

  5. Loetscher P et al (1996) Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release. J Immunol 156(1):322–327

    CAS  PubMed  Google Scholar 

  6. Kameyoshi Y et al (1992) Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176(2):587–592

    Article  CAS  PubMed  Google Scholar 

  7. Mattoli S et al (1995) Mast cell chemotactic activity of RANTES. Biochem Biophys Res Commun 209(1):316–321

    Article  CAS  PubMed  Google Scholar 

  8. Fine JS et al (2001) Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis. Inflammation 25(2):61–67

    Article  CAS  PubMed  Google Scholar 

  9. Cross AK, Woodroofe MN (1999) Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. J Neurosci Res 55(1):17–23

    Article  CAS  PubMed  Google Scholar 

  10. Appay V, Rowland-Jones SL (2001) RANTES: a versatile and controversial chemokine. Trends Immunol 22(2):83–87

    Article  CAS  PubMed  Google Scholar 

  11. Tavakkoly-Bazzaz J et al (2011) RANTES gene mRNA expression and its −403 G/A promoter polymorphism in coronary artery disease. Gene 487(1):103–106

    Article  CAS  PubMed  Google Scholar 

  12. Amoli MM et al (2009) Regulated upon activation normal T-cell expressed and secreted (RANTES) and epithelial cell-derived neutrophil-activating peptide (ENA-78) gene polymorphisms in patients with biopsy-proven erythema nodosum. Clin Exp Rheumatol 27(1 Suppl 52):S142–S143

    CAS  PubMed  Google Scholar 

  13. Fung K et al (2002) Genetic basis of familial Meniere’s disease. J Otolaryngol 31(1):1–4

    Article  PubMed  Google Scholar 

  14. Wassef M (2009) Pathology of the ear. Ann Pathol 29(4):347–360

    Article  PubMed  Google Scholar 

  15. da Costa SS, de Sousa LC, Piza MR (2002) Meniere’s disease: overview, epidemiology, and natural history. Otolaryngol Clin North Am 35(3):455–495

    Article  PubMed  Google Scholar 

  16. Mancini F et al (2002) History of Meniere’s disease and its clinical presentation. Otolaryngol Clin North Am 35(3):565–580

    Article  PubMed  Google Scholar 

  17. Pulec, J.L., Meniere’s disease of syphilitic etiology. Ear Nose Throat J, 1997. 76(8): p. 508-10, 512 514, passim

  18. Hajeer AH (1999) F. al Sharif, and W.E. Ollier, A polymorphism at position −403 in the human RANTES promoter. Eur J Immunogenet 26(5):375–376

    Article  CAS  PubMed  Google Scholar 

  19. Morrison AW et al (1994) On genetic and environmental factors in Meniere’s disease. Am J Otol 15(1):35–39

    CAS  PubMed  Google Scholar 

  20. Klar J et al (2006) A Meniere’s disease gene linked to chromosome 12p12.3. Am J Med Genet B Neuropsychiatr Genet 141B(5):463–467

    Article  CAS  PubMed  Google Scholar 

  21. Berlinger NT (2011) Meniere’s disease: new concepts, new treatments. Minn Med 94(11):33–36

    PubMed  Google Scholar 

  22. Navratilova Z (2006) Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150(2):191–204

    Article  CAS  PubMed  Google Scholar 

  23. Fryer AA et al (2000) The −403G>A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun 1(8):509–514

    Article  CAS  PubMed  Google Scholar 

  24. Schall TJ et al (1990) Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 347(6294):669–671

    Article  CAS  PubMed  Google Scholar 

  25. Sorensen TL et al (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103(6):807–815

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Snowden N et al (1994) RANTES role in rheumatoid arthritis. Lancet 343(8896):547–548

    Article  CAS  PubMed  Google Scholar 

  27. Takada T et al (2001) Polymorphism in RANTES chemokine promoter affects extent of sarcoidosis in a Japanese population. Tissue Antigens 58(5):293–298

    Article  CAS  PubMed  Google Scholar 

  28. Simeoni E et al (2004) Association of RANTES G−1alpha: impact on403A gene polymorphism with increased risk of coronary arteriosclerosis. Eur Heart J 25(16):1438–1446

    Article  CAS  PubMed  Google Scholar 

  29. Weyrich AS, Prescott SM, Zimmerman GA (2002) Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. Circulation 106(12):1433–1435

    Article  PubMed  Google Scholar 

  30. Lindemann S et al (2001) Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 154(3):485–490

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. von Hundelshausen P et al (2001) RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103(13):1772–1777

  32. Makki RF et al (2000) RANTES gene polymorphism in polymyalgia rheumatica, giant cell arteritis and rheumatoid arthritis. Clin Exp Rheumatol 18(3):391–393

    CAS  PubMed  Google Scholar 

  33. Mlynarski WM et al (2005) Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect. Diabetes 54(11):3331–3335

    Article  CAS  PubMed  Google Scholar 

  34. Chen Y et al (2004) Chemokine gene polymorphisms associate with gender in patients with uveitis. Tissue Antigens 63(1):41–45

    Article  CAS  PubMed  Google Scholar 

  35. Laplana M, Fibla J (2012) Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals. Cytokine 58(1):10–13

    Article  CAS  PubMed  Google Scholar 

  36. Eskes T, Haanen C (2007) Why do women live longer than men? Eur J Obstet Gynecol Reprod Biol 133(2):126–133

    Article  PubMed  Google Scholar 

  37. Yang Y, Kozloski M (2011) Sex differences in age trajectories of physiological dysregulation: inflammation, metabolic syndrome, and allostatic load. J Gerontol A Biol Sci Med Sci 66(5):493–500

    Article  PubMed  Google Scholar 

  38. Gonzalez E et al (2001) Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci U S A 98(9):5199–5204

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  39. Liu H et al (1999) Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci U S A 96(8):4581–4585

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Nasrin Yazdani, Motahareh Taleba, Farzaneh Nejadian & Mohammadtaghi Khorsandi ashtiani

  2. Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Marzieh Mojbafan

  3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Parvin Amiri & Mahsa M. Amoli

  4. Dr Shariati Hospital, North Karegar St., 14114, Tehran, Iran

    Mahsa M. Amoli

Authors
  1. Nasrin Yazdani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marzieh Mojbafan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Motahareh Taleba
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Parvin Amiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Farzaneh Nejadian
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mohammadtaghi Khorsandi ashtiani
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mahsa M. Amoli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mahsa M. Amoli.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yazdani, N., Mojbafan, M., Taleba, M. et al. Sex-specific association of RANTES gene −403 variant in Meniere’s disease. Eur Arch Otorhinolaryngol 272, 2221–2225 (2015). https://doi.org/10.1007/s00405-014-3151-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-014-3151-y

Keyword

Search

Navigation