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Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation

  • Otology
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Abstract

The purpose of the study is to assess the effect of a novel quorum sensing inhibitor (QSI), coded as ‘yd 47’, against otitis media and biofilm formation on Cochlear implants (CIs). Small pieces cut from cochlear implant were implanted under the skin in the retroauricular area on both sides of four guinea pigs. The implant pieces in the study and control sides were implanted in Streptococcus pneumoniae strain solution and saline, respectively. The right and left middle ears were also instilled with a solution containing pneumococci and saline, respectively. The animals were only given an intraperitoneal ‘yd 47’ twice daily for three months to be assessed later with electron microscopy. Clinical examination with palpation, inspection and otoscopy did not reveal any sign of implant infection or otitis media. In the study and control implant materials, soft tissues around the implant and tympanic membranes, there was no biofilm formation by pneumococci. Contamination by various cells and some rod-shaped bacteria (not diplococcic) were seen in some of the materials. In conclusion, the novel QSI seems promising in the prevention of otitis media and biofilm formation on CIs by pneumococci.

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Acknowledgments

We thank to Prof. Dr. Zekiye Suludere for scanning electron microscopic examination.

Conflict of interest

This study was supported financialy by MEDers® company (Authorized Distrubutor of MED-EL® company in Turkey). I (we) certifiy that we don’t have any interest in this company.

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Authors and Affiliations

  1. Otorhinolaryngology Department, Medipol University Faculty of Medicine, Bağcılar, 34200, Istanbul, Turkey

    Raşit Cevizci & Yıldırım A. Bayazıt

  2. Otorhinolaryngology Department, Gazi University Faculty of Medicine, Ankara, Turkey

    Mehmet Düzlü & Hakan Tutar

  3. Gazi University Faculty of Pharmacy, Ankara, Turkey

    Yasemin Dündar & Ningur Noyanalpan

  4. Microbiology Department, Gazi University Faculty of Medicine, Ankara, Turkey

    Nedim Sultan

Authors
  1. Raşit Cevizci
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  2. Mehmet Düzlü
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  3. Yasemin Dündar
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  4. Ningur Noyanalpan
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  5. Nedim Sultan
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  6. Hakan Tutar
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  7. Yıldırım A. Bayazıt
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Correspondence to Raşit Cevizci.

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Cevizci, R., Düzlü, M., Dündar, Y. et al. Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation. Eur Arch Otorhinolaryngol 272, 1389–1393 (2015). https://doi.org/10.1007/s00405-014-2942-5

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  • DOI: https://doi.org/10.1007/s00405-014-2942-5

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