Abstract
The aim of our study is to evaluate the status of selenium and zinc in nasal polyp tissues and to investigate the possible role of trace elements and antioxidants including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in nasal polyps. In this study, the antioxidant enzyme and trace element levels measured in polyp tissues of 37 patients were compared with the levels measured in conchal mucosa of 27 control cases. The antioxidant enzyme and trace element levels in tissues were measured with graphite and flame spectrophotometry methods using Shimatsu UV.1601 spectrophotometer and Perkin Elmer atomic spectrometer. The mean tissue zinc and selenium levels were, respectively, 2.55 μg/g and 30.03 pg/g in patient group, 4.37 μg/g and 44.95 pg/g in control group. The mean tissue SOD and GSH-Px levels were, respectively, 4.27 and 0.69 U/mg protein in patient group, 7.09 and 0.77 U/mg protein in control group. When the measured levels in patients and control cases were compared, there were statistically significant differences between zinc, selenium, and SOD levels (P = 0.001). There was no significant difference between GSH-Px levels (P = 0.465). In conclusion, it has been revealed that the levels of zinc, selenium, and SOD in nasal polyps were significantly lower, and it may be concluded that this may have a role in the development of nasal polyps.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dogru H, Delibas N, Doner F et al (2001) Free radical damage in nasal polyp tissue. Otolaryngol Head Neck Surg 124(5):570–572
Dagli M, Eryilmaz A, Besler T et al (2004) Role of free radicals and antioxidants in nasal polyps. Laryngoscope 114(7):1200–1203
Okur E, Inanc F, Yildirim I et al (2006) Malondialdehyde level and adenosine deaminase activity in nasal polyps. Otolaryngol Head Neck Surg 134(1):37–40
Papp LV, Lu J, Holmgren A et al (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 9(7):775–806
Zalewski PD, Truong-Tran AQ, Grosser D et al (2005) Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. Pharmacol Ther 105(2):127–149
Correia PRM, Oliveira E, Oliveira PV (2002) Simultaneous determination of manganese and selenium in serum by electrothermal atomic absorption spectrometry. Talanta 57(3):527–535
Smith JC, Butrimovitz GP, Purdy WC (1979) Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 25(8):1487–1491
Beutler E (1975) Red cell metabolism, 2nd edn. Grune and Stratton Company, New York, pp 261–265
Fridovich I (1974) Superoxide dismutase. Adv Enzymal 41:35–97
Lowry OH, Roseborough NJ, Farr AL et al (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275
Cekin E, Ipcioglu OM, Erkul BE et al (2009) The association of oxidative stress and nasal polyposis. J Int Med Res 37(2):325–330
Rostkowska-Nadolska B, Borawska M, Hukalowicz K (2005) Trace elements in nasal polyps. Biol Trace Elem Res 106:117–121
Selenius M, Rundlöf AK, Olm E et al (2010) Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer. Antioxid Redox Signal 12(7):867–880
Miller AL (2001) The etiologies, pathophysiology, and alternative/complementary treatment of asthma. Altern Med Rev 6(1):20–47
Truong-Tran AQ, Carter J, Ruffin R et al (2001) New insights into the role of zinc in the respiratory epithelium. Immunol Cell Biol 79(2):170–177
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Okur, E., Gul, A., Kilinc, M. et al. Trace elements in nasal polyps. Eur Arch Otorhinolaryngol 270, 2245–2248 (2013). https://doi.org/10.1007/s00405-012-2319-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-012-2319-6