European Archives of Oto-Rhino-Laryngology

, Volume 270, Issue 3, pp 1131–1136 | Cite as

Evaluation of quality of life in patients with obstructive sleep apnea

  • Alimohamad Asghari
  • Fatemeh Mohammadi
  • Seyed Kamran Kamrava
  • Maryam Jalessi
  • Mohammad Farhadi
Head and Neck

Abstract

Obstructive sleep apnea (OSA) is a common sleep disorder affecting quality of life. The aim of this study was to evaluate the perception of Quality of Life (QOL) in patients with OSA by means of World Health Organization Quality of Life (WHOQOL-BREF) instrument. This study was conducted on adult patients with sleep problems referred to Noor Sleep Lab for an overnight sleep study. Subjects were assessed for QOL using WHOQOL-BREF questionnaire. The Epworth sleepiness scale (ESS) was also employed to assess excessive daytime sleepiness (EDS). Baseline characteristics, ESS, and measured QOL are reported and their correlations with QOL were examined. Out of 502 patients included in the study, 62.7 % had moderate to severe OSA. The mean score of QOL in physical domain was significantly lower compared with normative population data. While AHI did not show any correlation with quality of life, mean O2 was weakly correlated with physical domain. Among the baseline characteristics, BMI and ESS were negatively correlated with physical and mental domains. Findings of this study show the impairment in quality of life related to physical functioning in patients with obstructive sleep apnea. Our study further supports the lack of association between AHI and QOL.

Keywords

Obstructive sleep apnea Quality of life Excessive daytime sleepiness Epworth sleepiness scale 

References

  1. 1.
    Epstein LJ, Kristo D, Strollo PJ, Friedman N, Malhotra A, Patil SP et al (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5(3):263–276PubMedGoogle Scholar
  2. 2.
    White DP (2006) Sleep apnea. Proc Am Thorac Soc 3:124–128PubMedCrossRefGoogle Scholar
  3. 3.
    Am Acad Sleep Med (2008) Obstructive sleep apnea. Am Acad Sleep Med, IllinoisGoogle Scholar
  4. 4.
    Flemons WW, Tsai W (1997) Quality of life consequences of sleep-disordered breathing. J Allergy Clin Immunol 99:s750–s756PubMedCrossRefGoogle Scholar
  5. 5.
    Lacasse Y (2006) Fundamentals of quality of life measurement. Sleep Med 7:s34–s35CrossRefGoogle Scholar
  6. 6.
    World health organization (1996) WHOQOL-Bref introduction, administration, scoring and generic version of the assessment. World health organization, GenevaGoogle Scholar
  7. 7.
    Lacasse Y, Godbout C, Series F (2002) Health-related quality of life in obstructive sleep apnea. Eur Respir J 19:499–503PubMedCrossRefGoogle Scholar
  8. 8.
    Stucki A, Cieza A, Schuurmans MM, Ustun B, Stucki G, Gradinger F et al (2008) Content comparison of health-related quality of life instruments for obstructive sleep apnea. Sleep Med 9:199–206PubMedCrossRefGoogle Scholar
  9. 9.
    Akashiba T, Kawahara S, Akahoshi T, Omori C, Saito O, Majima T et al (2002) Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. Chest 122:861–865PubMedCrossRefGoogle Scholar
  10. 10.
    Tsara V, Kaimakamis E, Serasli E, Katsarou Z, Christaki P (2008) Health related quality of life in Greek patients with sleep apnea–hypopnea syndrome treated with continuous positive airway pressure. Sleep Med. doi:10.1016/j.sleep.2007.12.008 PubMedGoogle Scholar
  11. 11.
    D’Ambrosio C, Bowman T, Mohsenin V (1999) Quality of life in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure—a prospective study. Chest 115:123–129PubMedCrossRefGoogle Scholar
  12. 12.
    Weaver EM, Woodson BT, Steward DL (2005) Polysomnography indexes are discordant with quality of life, symptoms, and reaction times in sleep apnea patients. Otolaryngol Head Neck Surg 132:255–262PubMedCrossRefGoogle Scholar
  13. 13.
    Moyer CA, Sonnad SS, Garetz SL, Hlman JI, Chervin RD (2001) Quality of life in obstructive sleep apnea: a systematic review of the literature. Sleep Med 2:477–491PubMedCrossRefGoogle Scholar
  14. 14.
    Walker- Engstrom ML, Wilhelmsson B, Tegelberg A, Dimenas E, Ringqvist I (2000) Quality of life assessment of treatment with dental appliance or UPPP in patients with mild to moderate obstructive sleep apnea. A prospective randomized 1-year follow-up study. J Sleep Res 9:303–308PubMedCrossRefGoogle Scholar
  15. 15.
    Li HY, Lin Y, Chen NH, Lee LA, Fang TJ, Wang PC (2008) Improvement in quality of life after nasal surgery alone for patients with obstructive sleep apnea and nasal obstruction. Arch Otolaryngol Head Neck Surg 134(4):429–433PubMedCrossRefGoogle Scholar
  16. 16.
    Parish JM, Lyng PJ (2003) Quality of life in bed partners of patients with obstructive sleep apnea or hypopnea after treatment with continuous positive airway pressure. Chest 124:942–947PubMedCrossRefGoogle Scholar
  17. 17.
    Lloberes P, Marti S, Sampol G, Roca A, Sagales T, Munoz X et al (2004) Predictive factors of quality of life improvement and continuous positive airway pressure use in patients with sleep apnea–hypopnea syndrome: study at 1 year. Chest 126:1241–1247PubMedCrossRefGoogle Scholar
  18. 18.
    Siccoli MM, Pepperell JCT, Kohler M, Craig SE, Davies RJO, Stradling JR (2008) Effects of continuous positive airway pressure on quality of life in patients with moderate to severe obstructive sleep apnea: data from a randomized controlled trial. Sleep 31(11):1551–1558PubMedGoogle Scholar
  19. 19.
    Silverberg DS, Iaina A, Oksenberg A (2002) Treating obstructive sleep apnea improves essential hypertension and quality of life. Am Fam Physician 65(2):229–236PubMedGoogle Scholar
  20. 20.
    Silva GE, An MW, Goodwin JL, Shahar E, Redline S, Resnick H et al (2009) Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the sleep heart health study (SHHS). Sleep 32(8):1049–1057PubMedGoogle Scholar
  21. 21.
    Pichel F, Zamarron C, Magan F, Campo FD, Sala RA, Suarez JRR (2004) Health-related quality of life in patients with obstructive sleep apnea: effects of long-term positive airway pressure treatment. Respir Med 98:968–976PubMedCrossRefGoogle Scholar
  22. 22.
    Profant J, Ancoli-Israel S, Dimsdale JE (2003) A randomized, controlled trial of 1 week of continuous positive airway pressure treatment on quality of life. Heart Lung 32:52–58PubMedCrossRefGoogle Scholar
  23. 23.
    Johns MW (1991) A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep 14(6):540–545PubMedGoogle Scholar
  24. 24.
    Nejat S, Montazeri A, Holakouie K, Mohammad K, Majdzadeh R (2008) Psychometric properties of the Iranian interview-administered version of the world health organization’s quality of life questionnaire (WHOQOL-Bref): a population-based study. BMC Health Serv Res 8:61–67CrossRefGoogle Scholar
  25. 25.
    American Academy of Sleep Medicine (2001) International classification of sleep disorders, revised: Diagnostic and coding manual. American Academy of Sleep Medicine, ChicagoGoogle Scholar
  26. 26.
    Nejat S, Naieni Holakouie K, Mohammad K, Majdzadeh R, Montazeri A (2011) Quality of life among an Iranian general population sample using the world health organization’s quality of life instrument (WHOQOL-BREF). INT J Public Health 56:55–61CrossRefGoogle Scholar
  27. 27.
    Margis R, Donis KC, S SV, Rieder CR (2010) WHOQOL-OLD assessment of quality of life in elderly patients with Parkinson’s disease: influence of sleep and depressive symptoms. Rev Bras Psiquiatr 32(2):125–131PubMedCrossRefGoogle Scholar
  28. 28.
    Theofilou P (2011) Quality of life in patients undergoing hemodialysis or peritoneal dialysis treatment. J Clin Med Res 3(3):132–138PubMedGoogle Scholar
  29. 29.
    Rovere H, Rossini S, Reimao R (2008) Quality of life in patients with narcolepsy. Arq Neuropsiquiatr 66(2-A):163–167PubMedCrossRefGoogle Scholar
  30. 30.
    Lasisi AO, Gureje O (2011) Prevalence of insomnia and impact on quality of life among community elderly with tinnitus. Ann Otol Rhinol Laryngol 120(4):226–230PubMedGoogle Scholar
  31. 31.
    Liu JC, Hung HL, Shyu YK, Tsai PS (2011) The impact of sleep quality and daytime sleepiness on global quality of life in community—dwelling patients with heart failure. J Cardiovasc Nurs 26:99–105PubMedGoogle Scholar
  32. 32.
    Kawahara S, Akashiba T, Akahoshi T, Horie T (2005) Nasal CPAP improves the quality of life and lessens the depressive symptoms in patients with obstructive sleep apnea syndrome. Intern Med 44(5):422–427PubMedCrossRefGoogle Scholar
  33. 33.
    Bolitschek J, Schmeiser- Rieder A, Schobersberger R, Rosenberger A, Kunze M, Aigner K (1998) Impact of nasal continuous positive airway pressure treatment on quality of life in patients with obstructive sleep apnea. Eur Respir J 11:890–894PubMedCrossRefGoogle Scholar
  34. 34.
    Zeitlhofer J, Schmeiser-Rieder A, Tribl G, Rosenberger A, Bolitschek J, Kapfhammer G et al (2000) Sleep and quality of life in the Austrian population. Acta Neurol Scand 102:249–257PubMedCrossRefGoogle Scholar
  35. 35.
    Asghari A, Farhadi M, Kamrava SK, Ghalehbaghi B, Nojomi M (2012) Subjective sleep quality in urban population. Arch Iran Med 15(2):95–98PubMedGoogle Scholar
  36. 36.
    Asghari A, Mohammadi F, Kamrava SK, Tavakoli S, Farhadi M (2012) Severity of depression and anxiety in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. doi:10.1007/s00405-012-1942-6 Google Scholar
  37. 37.
    Jing J, Huang T, Cui W, Shen H (2008) Effect on quality of life of continuous positive airway pressure in patients with obstructive sleep apnea syndrome: a meta-analysis. Lung 186:131–144PubMedCrossRefGoogle Scholar
  38. 38.
    Sirtori A, Brunani A, Villa V, Berselli ME, Croci M, Leonardi M et al (2012) Obesity is a marker of reduction in QOL and disability. Sci World J. doi:10.1100/2012/167520 Google Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Alimohamad Asghari
    • 1
  • Fatemeh Mohammadi
    • 1
  • Seyed Kamran Kamrava
    • 1
  • Maryam Jalessi
    • 1
  • Mohammad Farhadi
    • 1
  1. 1.Department and Research Center of Otolaryngology, Head and Neck Surgery, Hazrat Rasoul Akram HospitalTehran University of Medical SciencesTehranIran

Personalised recommendations