European Archives of Oto-Rhino-Laryngology

, Volume 270, Issue 4, pp 1203–1208 | Cite as

Oxidative stress in chronic otitis media

  • Elif BaysalEmail author
  • Nurten Aksoy
  • Ferit Kara
  • Seyithan Taysi
  • Abdullah Taşkın
  • Hasan Bilinç
  • Cengiz Cevik
  • Fatih Celenk
  • Muzaffer Kanlıkama


Chronic otitis media usually presents with a benign tumor-like lesion of the temporal bone known as a cholesteatoma. The role of oxidative stress in the pathogenesis of chronic otitis media and cholesteatoma has not yet been fully explored. Therefore, the aim of this study was to investigate the oxidative stress markers and antioxidant enzymes in patients with cholesteatomatous and noncholesteatomatous chronic otitis media and in healthy subjects. A prospective controlled trial was performed on cholesteatomatous and noncholesteatomatous chronic otitis media patients in a tertiary referral center in a university hospital. A total of 75 subjects, including 25 cholesteatomatous and 25 noncholesteatomatous chronic otitis media patients and 25 healthy subjects participated in this study. Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly increased in the patient groups with or without cholesteatoma compared with the control group. Serum total antioxidant status (TAS) levels and Paraoxonase and arylesterase activity were significantly lower in the patient groups with or without cholesteatoma compared with the control group. Serum TOS and OSI levels were lower in the noncholesteatomatous group, whereas serum TAS levels were higher compared with the cholesteatomatous group. Serum arylesterase activity was significantly lower in the noncholesteatomatous group compared with the control group. The results of this study reveal that in cholesteatoma cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in cases of chronic otitis media without cholesteatoma.


Chronic otitis media Cholesteatoma Oxidative stress Paraoxonase Prolidase 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Elif Baysal
    • 1
    Email author
  • Nurten Aksoy
    • 2
  • Ferit Kara
    • 3
  • Seyithan Taysi
    • 4
  • Abdullah Taşkın
    • 2
  • Hasan Bilinç
    • 2
  • Cengiz Cevik
    • 5
  • Fatih Celenk
    • 1
  • Muzaffer Kanlıkama
    • 1
  1. 1.Department of Otolaryngology, Medical FacultyGaziantep UniversityGaziantepTurkey
  2. 2.Department of Biochemistry, Medical FacultyHarran UniversitySanliurfaTurkey
  3. 3.Department of OtolaryngologyKahta State HospitalAdiyamanTurkey
  4. 4.Department of Biochemistry, Medical FacultyGaziantep UniversityGaziantepTurkey
  5. 5.Department of Otolaryngology, Medical FacultyMustafa Kemal UniversityHatayTurkey

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