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Histological evaluation of rat larynx in experimental polycystic ovary syndrome model

  • Laryngology
  • Published:
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Abstract

This study aimed at studying the histopathological effects of hyperandrogenemia and estrogen deficiency on larynx mucosa in experimentally designed polycystic ovary syndrome of female rats. Two groups of experimental polycystic ovary syndrome model were composed in healthy female rats by per oral letrozole administration of for 21 and 42 days. Also a control group which only took vehicle (saline) for 42 days was designed. Laryngeal mucosa and ovaries of all animals were examined histopathologically by light microscopy and the serum hormone levels were analyzed using a solid-phase, two-site chemiluminescent enzyme immunometric assay. Statistically significant edema, vascular engorgement, inflammation, cilia loss and differentiation of goblet cell distribution were observed when the control group and study groups were compared (p < 0.01). In serum hormonal analysis there was a significant increase in levels of androgens and decrease in levels of estrogens. In addition, polycystic appearance of ovaries in letrozole-administered groups and normal appearance of ovaries in control group have been proven histopathologically. Polycystic ovary syndrome which causes estrogen deficiency and hyperandrogenemia in fertile ages resulted in histopathological changes in laryngeal mucosa.

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Conflict of interest

We do not have any financial relationship with the organization that sponsored the research nor conflict of interest.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Fatih Sultan Mehmet Education and Research Hospital, E-5 üzeri Bostancı, 34744, Istanbul, Turkey

    Hande Senem Deveci

  2. Department of Otolaryngology-Head and Neck Surgery, Pasabahce Goverment Hospital, Istanbul, Turkey

    Ildem Deveci

  3. Department of Otolaryngology-Head and Neck Surgery, Umraniye Education and Research Hospital, Istanbul, Turkey

    Mehmet Habesoglu

  4. Department of Otolaryngology-Head and Neck Surgery, Karaman Goverment Hospital, Karaman, Turkey

    Mehmet Sürmeli

  5. Department of Otolaryngology-Head and Neck Surgery, Diyarbakir Dicle University Hospital, Diyarbakır, Turkey

    Vefa Kınıs

  6. Department of Otolaryngology-Head and Neck Surgery, Diyarbakir Ergani Goverment Hospital, Diyarbakır, Turkey

    Murat Eriman

  7. Department of Pathology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey

    Pembegul Gunes

  8. Department of Medical Biochemistry, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey

    Murat Yekrek

  9. Department of Otolaryngology-Head and Neck Surgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey

    Erol Egeli

Authors
  1. Hande Senem Deveci
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  2. Ildem Deveci
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  3. Mehmet Habesoglu
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  4. Mehmet Sürmeli
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  5. Vefa Kınıs
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  6. Murat Eriman
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  7. Pembegul Gunes
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  8. Murat Yekrek
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  9. Erol Egeli
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Corresponding author

Correspondence to Hande Senem Deveci.

Additional information

The study was done in Haydarpaşa Numune Education and Research Hospital.

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Deveci, H.S., Deveci, I., Habesoglu, M. et al. Histological evaluation of rat larynx in experimental polycystic ovary syndrome model. Eur Arch Otorhinolaryngol 269, 1945–1950 (2012). https://doi.org/10.1007/s00405-012-1978-7

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  • DOI: https://doi.org/10.1007/s00405-012-1978-7

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