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Clinical and histologic features of inverted papilloma–associated malignancy

  • Rhinology
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Abstract

The objectives of the study were to analyze the clinical features of inverted papillomas (IP) associated with malignancy and to evaluate the correlation of tumor stage, survival and histolologic features. We conducted a retrospective review of 18 IP associated with malignancy patients. In addition, we compared histopathologic characteristics (tumor differentiation and malignant cell proportion) with clinical outcomes. Eleven of the tumors were present on the nasal cavity and 7 on the maxillary sinus. The rates of synchronous and metachronous malignancy were 10.1 and 1.1%, respectively. The disease-free survival rate was 83.3%. The tumors were staged as T1 (5/18), T2 (2/18), T3 (8/18), and T4 (3/18). According to the percentage of the malignant cell in the entire tumor tissue, 4 patients (22%) were in grade I, 4 patients (22%) were in grade II, 3 patients (17%) were in grade III, and 7 patients (39%) were in grade IV. There was no relationship between recurrence- and/or disease-free survival and histologic findings including tumor differentiation and malignant proportion. IP-associated malignancy tends to occur synchronously and have more favorable prognosis compared to other sinonasal malignancy. Furthermore, the proportion of malignant cell to IP and tumor stage seems not to affect the clinical outcome of IP-associated malignancy.

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The authors report no conflicts of interest.

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Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Chungnam National University, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-721, South Korea

    Jin Woong Choi, Sun Gui Kim, Yong-Min Kim, Yeo-Hoon Yoon & Ki-Sang Rha

  2. Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, Korea

    Yong-Min Kim, Yeo-Hoon Yoon & Ki-Sang Rha

  3. Department of Otolaryngology-Head and Neck Surgery, EulJi University Hospital, Daejeon, Korea

    Ah Young Kim

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  1. Jin Woong Choi
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  2. Sun Gui Kim
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  3. Yong-Min Kim
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  4. Yeo-Hoon Yoon
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  5. Ah Young Kim
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  6. Ki-Sang Rha
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Correspondence to Ki-Sang Rha.

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Choi, J.W., Kim, S.G., Kim, YM. et al. Clinical and histologic features of inverted papilloma–associated malignancy. Eur Arch Otorhinolaryngol 269, 2349–2354 (2012). https://doi.org/10.1007/s00405-012-1935-5

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  • DOI: https://doi.org/10.1007/s00405-012-1935-5

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