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Cochlear implantation outcomes in children with Waardenburg syndrome

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Waardenburg syndrome (WS) is an autosomal dominant disease, characterized by dystopia canthorum, hyperplasia of the eyebrows, heterochromia iridis, white forelock, and congenital sensori-neural hearing loss (SNHL). The aim of this study was to evaluate the outcome of cochlear implantation in children with WS and compare it with children with pure SNHL. In a prospective study we evaluated 336 cochlear implanted children from 2008 to 2010. The WS was diagnosed by its established criteria and for control group children without any dysmorphic features, anatomical, behavioral, and developmental disorders were also enrolled. We evaluated children of both groups 1 year after cochlear implantation by categories of auditory performance (CAP) and speech intelligibility rating (SIR) tests. Eighty-one children out of the total 336 who had SNHL were included in study. Out of these 75 (22.3%) were healthy and six (1.78%) had WS. Of the 75 healthy children 40 (53.3%) were girls, while of the six children with WS, three (50%) were girls. There was a significant difference in SIR between WS and cases with pure SNHL (2.67 ± 1.03 vs. 3.79 ± 1.11, p = 021) however, the difference was not significant in CAP (4 ± 1.26 vs. 5.13 ± 1.13, p = 0.082). Prevalence of WS was 1.78% at Baqiyatallah Cochlear Implant Center. One year after implantation there was no significant difference in auditory outcome; however, the difference in speech outcome was significant between WS and cases with pure SNHL.

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Acknowledgments

The authors thank parents of children who kindly participated in this investigation. The authors would also like to express their gratitude to Dr. Mohsen Reza Haidari for reviewing and meticulous extensive editing of the English text.

Conflict of interest

None of authors have conflict of interest.

Author information

Authors and Affiliations

  1. Pediatric Neurology, Cochlear Implantation Research Center, Baqiyatallah University of Medical Sciences, Tehran, I. R. Iran

    Susan Amirsalari

  2. ENT, Cochlear Implantation Research Center, Baqiyatallah University of Medical Sciences, Tehran, I. R. Iran

    Mohammad Ajallouyean

  3. Health Research Center, Baqiyatallah University of Medical Sciences, Mollasadra St, Tehran, I. R. Iran

    Amin Saburi

  4. Cochlear Implantation Research Center, Baqiyatallah University of Medical Sciences, Tehran, I. R. Iran

    Adel Haddadi fard

  5. Audiology, Cochlear Implantation Research Center, Baqiyatallah University of Medical Sciences, Tehran, I. R. Iran

    Maryam Abed

  6. Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran

    Yasaman Ghazavi

Authors
  1. Susan Amirsalari
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  2. Mohammad Ajallouyean
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  3. Amin Saburi
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  4. Adel Haddadi fard
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  5. Maryam Abed
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  6. Yasaman Ghazavi
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Corresponding author

Correspondence to Amin Saburi.

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Amirsalari, S., Ajallouyean, M., Saburi, A. et al. Cochlear implantation outcomes in children with Waardenburg syndrome. Eur Arch Otorhinolaryngol 269, 2179–2183 (2012). https://doi.org/10.1007/s00405-011-1877-3

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  • DOI: https://doi.org/10.1007/s00405-011-1877-3

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