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Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas

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Abstract

The objective of this study was to assess angiogenic activity by analyzing anti-CD105 and anti-CD34 immunostaining in 20 cases of vascular malformations (VMs) and 20 cases of oral pyogenic granulomas (OPG). In addition, the usefulness of these markers for the differential diagnosis of these two oral tumors was evaluated. The results showed no significant difference in mean microvessel count between the anti-CD105 (P = 0.803) and anti-CD34 (P = 0.279) antibody. The mean number of vessels was 18.75 and 59.72 for oral VMs immunostained with anti-CD105 and anti-CD34 antibody, respectively, whereas in OPG the mean number was 20.22 and 48.09, respectively. CD34 was found to be more effective than CD105 in identifying blood vessels. However, the anti-CD105 antibody seems to be more related to vascular neoformation. Overall, this study supports the role of angiogenic factors in the etiopathogenesis of oral VMs and PG, but the results showed that quantification of angiogenesis cannot be used as a marker for the differential diagnosis of these two types of lesions.

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Authors and Affiliations

  1. Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Marcelo Gadelha Vasconcelos, Rodrigo Gadelha Vasconcelos, Éricka Janine Dantas da Silveira, Ana Miryam Costa Medeiros & Lélia Maria Guedes de Queiroz

  2. Dentistry Departament, State’s University of Paraíba, Campina Grande, PB, Brazil

    Pollianna Muniz Alves

  3. Departamento de Odontologia, UFRN–Programa de Pós-Graduação em Patologia Oral, Av. Salgado Filho, 1787, Lagoa Nova, Natal, RN, 59056-000, Brazil

    Éricka Janine Dantas da Silveira

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  1. Marcelo Gadelha Vasconcelos
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  2. Pollianna Muniz Alves
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  3. Rodrigo Gadelha Vasconcelos
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  4. Éricka Janine Dantas da Silveira
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  5. Ana Miryam Costa Medeiros
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  6. Lélia Maria Guedes de Queiroz
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Correspondence to Éricka Janine Dantas da Silveira.

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Vasconcelos, M.G., Alves, P.M., Vasconcelos, R.G. et al. Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas. Eur Arch Otorhinolaryngol 268, 1213–1217 (2011). https://doi.org/10.1007/s00405-010-1472-z

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  • DOI: https://doi.org/10.1007/s00405-010-1472-z

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