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Changes in expression of oncogenes and TP53 tumour suppressor gene as biomarkers in head and neck cancers

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Despite modern diagnostic procedures and up-to-date therapy, the survival of head and neck tumour patients is unfavourable. This can be explained by several factors, one of which is the late recognition of the tumour. This study related to the changes in expression of the c-myc and Ha-ras oncogenes and the p53 tumour suppressor gene as biomarkers in head and neck cancer cases. The gene expressions were investigated on RNA gained from peripheral white blood cells of head and neck cancers patients before and after definitive treatment. The results were compared with those on a control group of patients with non-tumorous diseases. The gene expressions were significantly higher in the cancer group than that in the control group (volunteer medical staff and medical students). After definitive treatment, the expressions of all these genes were decreased in patients in whom there was no recurrence of the tumour, but enhanced in the event of recurrence. Such measurement may serve as reliable biomarkers to monitor tumour development and the efficiency of therapy. The method may also be useful for the early identification of populations exposed to noxe, which may lead to the development of head and neck cancers.

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Acknowledgments

The authors wish to extend their special thanks to Mrs Zsuzsa Bayer-Brunner, Ms Mónika Herczeg, Mrs Mária Szegődi-Jankovics and Ms Csilla Gondos for excellent technical assistance.

Conflict of interest

There are no financial contributions to the work. The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Otolaryngology Head and Neck Surgery, Pécs University, Munkácsy Str 2, Pécs, 7621, Hungary

    István Szanyi, Miklós Bauer, Imre Gerlinger, Tamás Járai, Gyula Gőbel, László Lujber & Éva Szabadi

  2. Faculty of Medicine, Department of Public Health, Pécs University, Szigeti Str 12, Pécs, 7624, Hungary

    Katalin Fehér, István Ember & István Kiss

  3. Faculty of Medicine, Department of Surgery, Pécs University, Ifjúság Str 13, Pécs, 7624, Hungary

    Ágoston Ember

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  1. István Szanyi
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  2. Miklós Bauer
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  3. Imre Gerlinger
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  4. Tamás Járai
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  8. Katalin Fehér
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  9. Ágoston Ember
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  10. István Ember
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  11. István Kiss
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Correspondence to István Szanyi.

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Szanyi, I., Bauer, M., Gerlinger, I. et al. Changes in expression of oncogenes and TP53 tumour suppressor gene as biomarkers in head and neck cancers. Eur Arch Otorhinolaryngol 268, 1041–1046 (2011). https://doi.org/10.1007/s00405-010-1425-6

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  • DOI: https://doi.org/10.1007/s00405-010-1425-6

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