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Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland

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Abstract

The occasional local recurrence of benign pleomorphic adenoma (PA) has generally been attributed to the vulnerability of the tumor capsule. Although some reports have also noted the presence of satellite tumors associated with PA recurrence, only few reports have focused on this issue. We paid special attention to the satellite lesions apart from the main tumors and discussed their frequency, origin, nature and the ways of treating them. A total of 108 specimens of primary parotid gland PA resected at the Okayama Saiseikai General Hospital from 1988 to 2008 were microscopically reviewed. Four (3.7%) patients displayed a main mass with satellite tumors in a single parotid gland. The immunohistochemical analysis of p53 and Ki-67 index showed no distinct difference between PAs with satellite tumors and those without. Satellite tumors surrounding the main mass of parotid PA is relatively rare. In most cases, such satellite tumors will arise from capsular perforation of the primary tumor cells. Preoperative evaluation to recognize the existence of satellite tumors would be important and capsular dissection should be discouraged. We could not find any evidence suggesting that primary PA with satellite tumors could be more biologically aggressive than those without.

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References

  1. Behnke EE (1982) Unilateral multiple benign mixed tumors of the parotid gland. Laryngoscope 92:1265–1268

    Article  PubMed  Google Scholar 

  2. Rosai J (1996) Major and minor salivary glands. In: Rosai J (ed) Ackerman’s Surgical Pathology, vol 1, 8th edn (Chap 12). Mosby, St. Louis, pp 815–850

    Google Scholar 

  3. Niparko JK, Beauchamp ML, Krause CJ et al (1986) Surgical treatment of recurrent pleomorphic adenoma of the parotid gland. Arch Otolaryngol Head Neck Surg 112:1180–1184

    CAS  PubMed  Google Scholar 

  4. Clairmont AA, Richardson GS, Hanna DC (1977) The pseudocapsule of pleomorphic adenomas (benign mixed tumors). Am J Surg 134:242–243

    Article  CAS  PubMed  Google Scholar 

  5. Patey DH, Thackray AC (1958) The treatment of parotid tumors in the light of pathological study of parotidectomy material. Br J Surg 45:477–487

    Article  CAS  PubMed  Google Scholar 

  6. Eneroth CM (1964) Histological and clinical aspects of parotid tumors. Acta Otolaryngol Suppl 191:1–99

    Google Scholar 

  7. Zbären P, Stauffer E (2007) Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck 29:751–757

    Article  PubMed  Google Scholar 

  8. Foote FW, Frazell EL (1953) Tumors of the major salivary glands. Cancer 6:1065–1133

    Article  PubMed  Google Scholar 

  9. Turnbull AD, Frazell EL (1969) Multiple tumors of the major salivary gland. Am J Surg 118:787–789

    Article  CAS  PubMed  Google Scholar 

  10. Krogdahl AS, Bretlau P, Hastrup N (1983) Multiple tumors of the parotid gland. J Laryngol Otol 97:1035–1037

    Article  CAS  PubMed  Google Scholar 

  11. Tanimoto H, Kumoi K, Otsuki N et al (2002) Multiple primary pleomorphic adenomas in a single parotid gland: report of a new case. Ear Nose Throat J 81:341–345

    PubMed  Google Scholar 

  12. Yu GY, Ma DQ, Peng ZX et al (2004) Multiple primary tumours of the parotid gland. Int J Oral Maxillofac Surg 33(6):531–534

    Article  PubMed  Google Scholar 

  13. Carlsöö B, Ekstrand T (1977) Unilateral multiple mixed tumours of the parotid gland. J Laryngol Otol 91(7):629–632

    Article  PubMed  Google Scholar 

  14. Azuma M, Kasai Y, Tamatani T et al (1992) Involvement of p53 mutation in the development of human salivary gland pleomorphic adenomas. Cancer Lett 65:61–71

    Article  CAS  PubMed  Google Scholar 

  15. Li X, Tsuji T, Wen S et al (1997) Detection of numeric abnormalities of chromosome 17 and p53 deletions by fluorescence in situ hybridization in pleomorphic adenomas and carcinomas in pleomorphic adenoma. Cancer 79:2314–2319

    Article  CAS  PubMed  Google Scholar 

  16. Tashiro T, Hirokawa M, Harada H et al (2002) Cell membrane expression of MIB-1 in salivary gland pleomorphic adenoma. Histopathology 41:559–567

    Article  CAS  PubMed  Google Scholar 

  17. Lazzaro B, Cleveland D (2000) p53 and ki-67 antigen expression in small oral biopsy specimens of salivary gland tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:613–617

    Article  CAS  PubMed  Google Scholar 

  18. Abbona GC, Papotti M, Gasparri G et al (1995) Proliferative activity in parathyroid tumors as detected by Ki-67 immunostaining. Hum Pathol 26:135–138

    Article  CAS  PubMed  Google Scholar 

  19. Woods JE, Chong GC, Beahrs OH (1975) Experience with 1360 primary parotid tumors. Am J Surg 130:460–462

    Article  CAS  PubMed  Google Scholar 

  20. Donovan DT, Conley JJ (1984) Capsular significance in parotid tumor surgery: reality and myths of lateral lobectomy. Laryngoscope 94:324–328

    Article  CAS  PubMed  Google Scholar 

  21. Lawson HH (1989) Capsular penetration and perforation in pleomorphic adenoma of the parotid salivary gland. Br J Surg 76:594–596

    Article  CAS  PubMed  Google Scholar 

  22. Gaynor EB, Hershberg R (1976) Unilateral multiple tumours of the parotid gland. J Laryngol Otol 90:295–298

    Article  CAS  PubMed  Google Scholar 

  23. Chen IH, Tu HY (2000) Pleomorphic adenoma of the parotid gland metastasizing to the cervical lymph node. Otolaryngol Head Neck Surg 122:455–457

    Article  CAS  PubMed  Google Scholar 

  24. Goodisson DW, Burr RGM, Creedon AJ et al (1999) A case of metastasizing pleomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87:341–345

    Article  CAS  PubMed  Google Scholar 

  25. McGurk M, Thomas BL, Renehan AG (2003) Extracapsular dissection for clinically benign parotid lumps: reduced morbidity without oncological compromise. Br J Cancer 89:1610–1613

    Article  CAS  PubMed  Google Scholar 

  26. Ghosh S, Panarese A, Bull PD et al (2003) Marginally excised parotid pleomorphic salivary adenomas: risk factors for recurrence and management. A 12.5-year mean follow-up study of histologically marginal excisions. Clin Otolaryngol 28:262–266

    Article  CAS  PubMed  Google Scholar 

  27. Stennert E, Guntinas-Lichius O, Klussmann JP et al (2001) Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases. Laryngoscope 111:2195–2200

    Article  CAS  PubMed  Google Scholar 

  28. Harris CC, Hollstein M (1993) Clinical implications of the p53 tumor-suppressor gene. N Eng J Med 329:1318

    Article  CAS  Google Scholar 

  29. Nordkvist A, Röijer E, Bang G et al (2000) Expression and mutation pattern of p53 in benign and malignant salivary gland tumors. Int J Oncol 16:477–483

    CAS  PubMed  Google Scholar 

  30. Kärjä VJ, Syrjänen KJ, Kurvinen AK et al (1997) Expression and mutations of p53 in salivary gland tumors. J Oral Pathol Med 26:217–223

    Article  PubMed  Google Scholar 

  31. Gallo O, Franchi A, Bianchi S et al (1995) p53 oncoprotein expression in parotid gland carcinoma is associated with clinical course. Cancer 75:2037–2044

    Article  CAS  PubMed  Google Scholar 

  32. Yamamoto Y, Kishimoto Y, Virmani AK et al (1996) Mutations associated with carcinomas arising from pleomorphic adenomas of the salivary glands. Human Pathol 27:782–786

    Article  CAS  Google Scholar 

  33. Gerdes J, Schwab U, Lemke H et al (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31:13

    Article  CAS  PubMed  Google Scholar 

  34. Katori H, Nozawa A, Tsukuda M (2007) Expression of epidermal growth factor receptor, transforming growth factor-α and Ki-67 in relationship to malignant transformation of pleomorphic adenoma. Acta Otolaryngol 127:1207–1213

    Article  CAS  PubMed  Google Scholar 

  35. Vargas PA, Cheng Y, Barrett AW et al (2008) Expression of Mcm-2. Ki-67 and geminin in benign and malignant salivary gland tumors. J Oral Pathol Med 37:309–318

    CAS  PubMed  Google Scholar 

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Conflict of interest statement

We have no conflict of interest, potential conflicts or financial relationships.

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Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Okayama Saiseikai General Hospital, 1-17-18, Ifuku-Cho, Okayama, 700-8511, Japan

    Yorihisa Orita, Kentaroh Miki, Akiko Sugaya, Misato Hirai & Kiyoko Nakai

  2. Department of Pathology, Okayama Saiseikai General Hospital, Okayama, Japan

    Kazuo Hamaya & Sohichiroh Nose

  3. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

    Tadashi Yoshino

Authors
  1. Yorihisa Orita
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  2. Kazuo Hamaya
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  3. Kentaroh Miki
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  4. Akiko Sugaya
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  5. Misato Hirai
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  6. Kiyoko Nakai
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  7. Sohichiroh Nose
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  8. Tadashi Yoshino
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Correspondence to Yorihisa Orita.

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Orita, Y., Hamaya, K., Miki, K. et al. Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland. Eur Arch Otorhinolaryngol 267, 801–806 (2010). https://doi.org/10.1007/s00405-009-1149-7

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  • DOI: https://doi.org/10.1007/s00405-009-1149-7

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