Skip to main content

Advertisement

SpringerLink
Log in

Level alterations of the 2f 1–f 2 distortion product due to hypoxia in the guinea pig depend on the stimulus frequency

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Increased intracranial pressure (ICP) is known to affect the levels of distortion product otoacoustic emissions (DPOAEs) in a frequency-specific manner. DPOAEs might, therefore, be used for monitoring the ICP non-invasively. Hypoxia can also cause alterations of DPOAE levels, which can be distinguished from ICP-related changes only, when their characteristics, in particular frequency specificity, are known in detail. DPOAEs at f 2 = 2, 4, 8, 12 and 16 kHz and oxygen saturation (SaO2) were continuously monitored in nine spontaneously breathing guinea pigs, anaesthetized by i.m. administration of midazolam, medetomidin and fentanyl, during the respiration of a gas mixture of N2O and O2 containing either 30% O2 or 13% O2. Fourteen hypoxic intervals in eight animals were included into final data analysis. Characteristic hypoxic level alterations with a level decrease and a remarkable level destabilization during hypoxia, and a pronounced reversible level decrease after reoxygenation were observed at the frequencies of 4, 8 and 16 kHz. At 2 and 12 kHz, the only reproducible effect of hypoxia was an increased fluctuation of the DPOAE level, which was significantly less pronounced compared with the other frequencies (P < 0.05 for 12 vs. 16 and 8 kHz and for 2 vs. 16 kHz). DPOAE level alterations due to hypoxia depend on the frequency in guinea pigs. Studies in human are warranted to improve non-invasive ICP monitoring with DPOAE by the detection of hypoxia-related changes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Czosnyka M, Pickard JD (2004) Monitoring and interpretation of intracranial pressure. J Neurol Neurosurg Psychiatry 75(6):813–821

    Article  CAS  PubMed  Google Scholar 

  2. Steiner LA, Andrews PJ (2006) Monitoring the injured brain: ICP and CBF. Br J Anaesth 97(1):26–38

    Article  CAS  PubMed  Google Scholar 

  3. Buki B, Chomicki A, Dordain M, Lemaire JJ, Wit HP, Chazal J, Avan P (2000) Middle-ear influence on otoacoustic emissions. II Contributions of posture and intracranial pressure. Hear Res 140(1–2):202–211

    Article  CAS  PubMed  Google Scholar 

  4. Frank AM, Alexiou C, Hulin P, Janssen T, Arnold W, Trappe AE (2000) Non-invasive measurement of intracranial pressure changes by otoacoustic emissions (OAEs): a report of preliminary data. Zentralbl Neurochir 61(4):177–180

    Article  CAS  PubMed  Google Scholar 

  5. Voss SE, Horton NJ, Tabucchi TH, Folowosele FO, Shera CA (2006) Posture-induced changes in distortion-product otoacoustic emissions and the potential for noninvasive monitoring of changes in intracranial pressure. Neurocrit Care 4(3):251–257

    Article  PubMed  Google Scholar 

  6. Plinkert PK, Ptok M (1994) Changes in transitory evoked otoacoustic emissions and acoustic distortion products in disorders of eustachian tube ventilation. HNO 42(7):434–440

    CAS  PubMed  Google Scholar 

  7. Cazals Y (2000) Auditory sensori-neural alterations induced by salicylate. Prog Neurobiol 62(6):583–631

    Article  CAS  PubMed  Google Scholar 

  8. Mills DM, Rubel EW (1994) Variation of distortion product otoacoustic emissions with furosemide injection. Hear Res 77(1–2):183–199

    Article  CAS  PubMed  Google Scholar 

  9. Shi Y, Martin WH (1997) ABR and DPOAE detection of cochlear damage by gentamicin. J Basic Clin Physiol Pharmacol 8(3):141–155

    CAS  PubMed  Google Scholar 

  10. Wake M, Anderson J, Takeno S, Mount RJ, Harrison RV (1996) Otoacoustic emission amplification after inner hair cell damage. Acta Otolaryngol 116(3):374–381

    Article  CAS  PubMed  Google Scholar 

  11. Suckfull M, Winkler G, Thein E, Raab S, Schorn K, Mees K (1999) Changes in serum osmolarity influence the function of outer hair cells. Acta Otolaryngol 119(3):316–321

    Article  CAS  PubMed  Google Scholar 

  12. Olzowy B, von Gleichenstein G, Canis M, Plesnila N, Mees K (2008) Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig. Eur Arch Otorhinolaryngol 265(11):1329–1333

    Article  PubMed  Google Scholar 

  13. Rebillard G, Lavigne-Rebillard M (1992) Effect of reversible hypoxia on the compared time courses of endocochlear potential and 2f1–f2 distortion products. Hear Res 62(2):142–148

    Article  CAS  PubMed  Google Scholar 

  14. Sawada S, Mori N, Mount RJ, Harrison RV (2001) Differential vulnerability of inner and outer hair cell systems to chronic mild hypoxia and glutamate ototoxicity: insights into the cause of auditory neuropathy. J Otolaryngol 30(2):106–114

    Article  CAS  PubMed  Google Scholar 

  15. Olzowy B, von Gleichenstein G, Canis M, Mees K (2008) Distortion product otoacoustic emissions for assessment of intracranial hypertension at extreme altitude? Eur J Appl Physiol 103:19–23

    Article  CAS  PubMed  Google Scholar 

  16. Frolenkov GI, Belyantseva IA, Kurc M, Mastroianni MA, Kachar B (1998) Cochlear outer hair cell electromotility can provide force for both low and high intensity distortion product otoacoustic emissions. Hear Res 126(1–2):67–74

    Article  CAS  PubMed  Google Scholar 

  17. Whitehead ML, Lonsbury-Martin BL, Martin GK (1992) Evidence for two discrete sources of 2f1–f2 distortion-product otoacoustic emission in rabbit. II Differential physiological vulnerability. J Acoust Soc Am 92(5):2662–2682

    Article  CAS  PubMed  Google Scholar 

  18. Michaelis CE, Gehr DD, Deingruber K, Arnold W, Lamm K (2004) Optimum primary tone level setting for measuring high amplitude DPOAEs in guinea pigs. Hear Res 189(1–2):58–62

    Article  PubMed  Google Scholar 

  19. Rebillard G, Klis JF, Lavigne-Rebillard M, Devaux P, Puel JL, Pujol R (1993) Changes in 2f1–f2 distortion product otoacoustic emissions following alterations of cochlear metabolism. Br J Audiol 27(2):117–121

    Article  CAS  PubMed  Google Scholar 

  20. Freeman S, Goitein K, Attias J, Furst M, Sohmer H (1995) Effect of hypoxemia and ethacrynic acid on ABR and distortion product emission thresholds. J Neurol Sci 131(1):21–29

    Article  CAS  PubMed  Google Scholar 

  21. Dallos P, Evans BN (1995) High-frequency motility of outer hair cells and the cochlear amplifier. Science 267(5206):2006–2009

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We like to thank Prof. Dr. Ulrich Pohl, director of the Walter Brendel Center for Experimental Medicine, for the opportunity to make our experiments in his laboratory and to use all facilities for experimental animals. We further like to thank the keepers who took care of our laboratory animals. The investigations were supported by the Program for Research and Teaching of the Faculty of Medicine of the University of Munich (Föderprogramm für Forschung und Lehre der Medizinischen Fakultät der Ludwig Maximilians Universität München, Reg.-Nr. 403).

Conflict of interest statement

None of the authors has any conflict of interest.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, Marchioninistr. 15, 81377, München, Germany

    Bernhard Olzowy, Martin Canis, Sebastian Strieth & Klaus Mees

  2. Institute of Surgical Research, Walter Brendel Center for Experimental Medicine, Ludwig Maximilians University of Munich, Marchioninistr. 15, 81377, Munich, Germany

    Bernhard Olzowy, Gregor von Gleichenstein, Nikolaus Plesnila & Christoph Deppe

Authors
  1. Bernhard Olzowy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gregor von Gleichenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martin Canis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nikolaus Plesnila
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sebastian Strieth
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Christoph Deppe
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Klaus Mees
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bernhard Olzowy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olzowy, B., von Gleichenstein, G., Canis, M. et al. Level alterations of the 2f 1–f 2 distortion product due to hypoxia in the guinea pig depend on the stimulus frequency. Eur Arch Otorhinolaryngol 267, 351–355 (2010). https://doi.org/10.1007/s00405-009-1052-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-009-1052-2

Keywords

Search

Navigation