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MMP-14 can serve as a prognostic marker in patients with supraglottic cancer

European Archives of Oto-Rhino-Laryngology volume 266, pages 1427–1434 (2009)Cite this article

Abstract

The purpose of this study was to examine the expression of MMP-14, 15 and 16 (MT1, MT2 and MT3-MMP) in supraglottic carcinoma and to explore their clinical significance. Expression of MMP-14, 15 and 16 was examined using RT-PCR and immunohistochemistry methods in samples from 85 cases of supraglottic carcinoma. Results showed that both mRNA and protein expression of MMP-14, 15 and 16 were increased in supraglottic carcinoma tissues compared to expression in control adjacent non-neoplastic tissues (P < 0.05). Expression of MMP-14, but not MMP-15 and MMP-16, was significantly increased in the T3 and neck nodal metastasis groups compared with the T1–2 group and the group without nodal metastasis at both mRNA and protein levels (P < 0.05). Expression of MMP-14 mRNA and protein was also higher in tumors of patients with stage III–IV disease compared to patients with clinical stage I–II tumors (P < 0.05). Kaplan–Meier survival curves showed that the groups with high MMP-14 protein expression had a poorer prognosis than patients in the groups with weak or negative expression of MMP-14 protein (P < 0.05). In conclusion, MMP-14 may play an important role in the progression of supraglottic carcinoma and may be a novel prognostic factor for patients with supraglottic carcinoma.

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Acknowledments

Granted by The Natural Science Foundation of China (30540010), the Postdoctoral Science Foundation of China (20070410920) and also by the Youth Foundation (QC06C054) and Natural Science Foundation (GC07C35106) of Heilongjiang Province, P.R. China.

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Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, 150086, Harbin, People’s Republic of China

    Huiyan Zhang, Ming Liu, Yanan Sun & Jianguang Lu

  2. Department of Otorhinolaryngology, Head and Neck Surgery, The 211 hospital of PLA, Harbin, People’s Republic of China

    Huiyan Zhang

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  1. Huiyan Zhang
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  2. Ming Liu
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  3. Yanan Sun
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  4. Jianguang Lu
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Correspondence to Yanan Sun.

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Huiyan Zhang and Ming Liu are co-first authors.

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Zhang, H., Liu, M., Sun, Y. et al. MMP-14 can serve as a prognostic marker in patients with supraglottic cancer. Eur Arch Otorhinolaryngol 266, 1427–1434 (2009). https://doi.org/10.1007/s00405-009-0943-6

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  • DOI: https://doi.org/10.1007/s00405-009-0943-6

Keywords

  • Supraglottic carcinoma
  • Membrane-type matrix metalloproteinases
  • Prognosis