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The value of local botulinum toxin A injection in the treatment of the pain of aphthous ulcer

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Abstract

To determine the effectiveness of botulinum toxin type A to reduce pain of recurrent aphthous ulcer, a single blinded placebo controlled trial of botulinum toxin A injection was performed. A total of 70 patients were enrolled and randomly received a botulinum toxin type A 1 unit or placebo. The patients were asked to note the level of pain on the visual analogue scale for 6 days. They also had to record any eventual side effects or recurrence for 6 months. More patients quickly recovered following Botulinum toxin type A injection than placebo; they would feel almost no pain after about 3 days. Botulinum toxin type A exhibits quick pain treatment effect following injection on aphthous ulcer. The author also believes that it can prevent recurrence for at least 6 months after injection.

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Acknowledgments

This article is supported by INHA University Research Grant.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Inha University, 3-Ga Shinheung-dong, Jung-Gu, Incheon, 400-711, South Korea

    Tae Yong Yang & Tae Young Jang

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  1. Tae Yong Yang
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  2. Tae Young Jang
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Correspondence to Tae Yong Yang.

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Yang, T.Y., Jang, T.Y. The value of local botulinum toxin A injection in the treatment of the pain of aphthous ulcer. Eur Arch Otorhinolaryngol 266, 445–448 (2009). https://doi.org/10.1007/s00405-008-0756-z

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  • DOI: https://doi.org/10.1007/s00405-008-0756-z

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