Abstract
Inflammatory myofibroblastic tumor (IMT) is a rare entity. It is usually found in the lung and upper respiratory tract. Its location in the thyroid is exceedingly rare. Only seven cases of IMT of the thyroid were reported in the literature, mostly after the age of 50 years. The predominant histological pattern in all previously reported cases is that of marked plasma cell infiltrate. We report the detailed clinico-pathological and immunophenotypical features of a case of IMT of the thyroid in an 18-year-old girl with a family history of goiter. Our case is unique because it is the first and only known case of IMT of the thyroid in its alternative sclerosing subtype.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bahadori M, Liebow M (1973) Plasma cell granuloma of the lung. Cancer 31:191–208. doi :10.1002/1097-0142(197301)31:1<191::AID-CNCR2820310127>3.0.CO;2-D
Jacobs D, Galetta S (2002) Diagnosis and management of orbital pseudotumor. Curr Opin Ophthalmol 13:347–351. doi:10.1097/00055735-200212000-00001
Ruaux C, Noret P, Godey B (2001) Inflammatory pseudotumour of the nasal cavity and sinuses. J Laryngol Otol 115:563–566. doi:10.1258/0022215011908234
Ereno C, López JI, Grande J et al (2001) Inflammatory myofibroblastic tumour of the larynx. J Laryngol Otol 115:856–858
Martinez F, Filipowicz E, Hudnall SD (2002) Plasma cell granuloma of the thyroid, a case report and review of the literature. Arch Pathol Lab Med 126:595–598
Coffin CM, Watterson J, Priest JR, Dehner LP (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19:859–872. doi:10.1097/00000478-199508000-00001
Thawley SE, Panje WR, Batsakis JG, Lindberg RD (1999) Granulomatous and lymphoproliferative diseases of the head and neck. In: Thawley SE, Panje WR, Batsakis JG, Lindberg RD (eds) Comprehensive management of head and neck tumors. WB Saunders, Philadelphia, pp 1163–1165
Van Dorpe J, Ectors N, Geboes K et al (1999) Is calcifying fibrous pseudotumor a late sclerosing stage of inflammatory myofibroblastic tumor? Am J Surg Pathol 23:329–335. doi:10.1097/00000478-199903000-00013
Arber DA, Kamel OW, Van de Rijn M (1995) Frequent presence of the Epstein-Barr virus in inflammatory pseudotumor. Hum Pathol 26:1093–1098. doi:10.1016/0046-8177(95)90271-6
Coffin CM, Patel A, Perkins S et al (2001) ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol 14:569–576. doi:10.1038/modpathol.3880352
Conflict of interest statement
The authors declare that they have no competing interests.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Trimeche, M., Ziadi, S., Mestiri, S. et al. Inflammatory myofibroblastic tumor of the thyroid in its sclerosing subtype: the first case report. Eur Arch Otorhinolaryngol 266, 763–766 (2009). https://doi.org/10.1007/s00405-008-0740-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00405-008-0740-7