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The influence of smoking on success of tympanoplasty measured by serum cotinine analysis

European Archives of Oto-Rhino-Laryngology volume 265, pages 513–516 (2008)Cite this article

Abstract

The aim of this study was to evaluate the effects of smoking on surgical outcome and hearing results in tympanoplasty by serum cotinine analysis as an objective method. Furthermore, type of grafting for the smoking patients has been investigated in a prospective cohort in a tertiary medical center. The overall success rate of long-term surgical outcome was 70.1% out of 77 tympanoplasty operations. On the basis of cotinine enzyme immunoassay, 56 patients had a serum cotinine measurement below 17.5 ng/ml and 21 patients above that. While the graft take rate in the non-smoking group was 76.8%, it was 52.4% in the smoking group and this difference was statistically significant (p = 0.037). While mean graft take rate in the temporalis fascia group was 25% for smokers, mean graft take rate in cartilage shield tympanoplasty group it was 88.9%, and for smokers it was 52.4%. Cotinine is a major metabolite of nicotine and is a reliable marker to differentiate smoking patients from non-smokers. Smoking status was found as a significant prognostic factor influencing the success rate of tympanoplasty negatively and the influence of a more stable grafting technique was demonstrated on smoking patients undergoing tympanoplasty procedure.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Ataturk Training and Research Hospital, Izmir, Turkey

    M. Zafer Uguz & Kazim Onal

  2. Department of Otorhinolaryngology, Ankara Military Hospital, Ankara, Turkey

    K. Cagdas Kazikdas

  3. Department of Pharmacology, Ege University School of Medicine, Izmir, Turkey

    Aytul Onal

  4. 173 sok. No: 20/8, 35360, Hatay, Izmir, Turkey

    K. Cagdas Kazikdas

Authors
  1. M. Zafer Uguz
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  2. Kazim Onal
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  3. K. Cagdas Kazikdas
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  4. Aytul Onal
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Correspondence to K. Cagdas Kazikdas.

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Uguz, M.Z., Onal, K., Kazikdas, K.C. et al. The influence of smoking on success of tympanoplasty measured by serum cotinine analysis. Eur Arch Otorhinolaryngol 265, 513–516 (2008). https://doi.org/10.1007/s00405-007-0485-8

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  • DOI: https://doi.org/10.1007/s00405-007-0485-8

Keywords

  • Cotinine
  • Smoking
  • Cartilage
  • Tympanoplasty